SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1awc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1awc PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus) 		4 / 4 THR B  54
LEU B  57
VAL B  22
LEU B  25
 None
 0.86A 1fbmD-1awcB:
0.0		 1fbmD-1awcB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1awc PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus) 		4 / 8 LEU B  75
VAL B 119
LEU B 122
ALA B 128
 None
 0.87A 1fiqC-1awcB:
0.0		 1fiqC-1awcB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1awc PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus) 		4 / 4 THR B  54
LEU B  57
VAL B  22
LEU B  25
 None
 0.92A 1mz9D-1awcB:
undetectable		 1mz9D-1awcB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus;
Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TRP B 110
HIS B 109
 None
 1.47A 2einN-1awcA:
undetectable
2einP-1awcA:
undetectable		 2einN-1awcA:
11.33
2einP-1awcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus;
Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TRP B 110
HIS B 109
 None
 1.47A 3ag1A-1awcA:
undetectable
3ag1C-1awcA:
undetectable		 3ag1A-1awcA:
11.33
3ag1C-1awcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus) 		5 / 12 THR B  39
THR B  68
LEU A 406
LEU B  44
TYR B  48
 None
 1.16A 3gwxB-1awcB:
undetectable		 3gwxB-1awcB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus) 		4 / 8 TRP B 110
THR A 331
VAL A 418
PHE B 136
 None
 0.96A 4ltwA-1awcB:
undetectable		 4ltwA-1awcB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
(Mus
musculus) 		5 / 8 ALA A 357
LEU A 322
LEU A 350
TYR A 371
LEU A 326
 None
 1.35A 5jqbA-1awcA:
0.0
5jqbB-1awcA:
0.7		 5jqbA-1awcA:
17.16
5jqbB-1awcA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
(Mus
musculus) 		5 / 12 GLY A 361
GLN A 324
LEU A 326
GLU A 328
LEU A 329
 None
 0.79A 5nwwA-1awcA:
0.0		 5nwwA-1awcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
(Mus
musculus) 		5 / 12 GLY A 361
GLN A 324
LEU A 327
GLU A 328
LEU A 329
 None
 0.91A 5nwwA-1awcA:
0.0		 5nwwA-1awcA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1awc PROTEIN (GA BINDING
PROTEIN ALPHA)
PROTEIN (GA BINDING
PROTEIN BETA 1)
(Mus
musculus;
Mus
musculus) 		4 / 6 ASP A 332
THR A 331
TRP B 110
HIS B 109
 None
 1.46A 5x19N-1awcA:
undetectable
5x19P-1awcA:
0.0		 5x19N-1awcA:
11.33
5x19P-1awcA:
17.65