SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ax8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ax8 OBESITY PROTEIN
(Homo
sapiens) 		4 / 6 TYR A  61
MET A  68
ILE A  64
SER A 132
 None
 1.18A 3pmzD-1ax8A:
undetectable		 3pmzD-1ax8A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1ax8 OBESITY PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  86
LEU A  83
ASN A  82
LEU A  80
VAL A  18
 None
 1.25A 3zqtA-1ax8A:
undetectable		 3zqtA-1ax8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1ax8 OBESITY PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 129
SER A 127
LEU A  65
MET A  68
ILE A  76
 None
 1.07A 4x1fA-1ax8A:
undetectable		 4x1fA-1ax8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1ax8 OBESITY PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 129
SER A 127
LEU A  65
MET A  68
ILE A  76
 None
 1.01A 4x1gA-1ax8A:
undetectable		 4x1gA-1ax8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1ax8 OBESITY PROTEIN
(Homo
sapiens) 		3 / 3 LYS A   3
LYS A  94
SER A  93
 None
 0.86A 5odiA-1ax8A:
undetectable		 5odiA-1ax8A:
13.04