SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1axd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 11 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 1lwcA-1axdA:
undetectable		 1lwcA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 11 TYR A 106
LEU A 143
HIS A 168
LEU A 156
LEU A 150
 None
 1.22A 1mrqA-1axdA:
undetectable		 1mrqA-1axdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 11 LEU A  21
ALA A  24
SER A 202
LEU A 163
LEU A 166
 None
 1.10A 1tz8A-1axdA:
undetectable
1tz8B-1axdA:
undetectable		 1tz8A-1axdA:
20.57
1tz8B-1axdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 11 LEU A 163
LEU A 166
LEU A  21
ALA A  24
SER A 202
 None
 1.13A 1tz8A-1axdA:
undetectable
1tz8B-1axdA:
undetectable		 1tz8A-1axdA:
20.57
1tz8B-1axdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.49A 2zd1A-1axdA:
0.0		 2zd1A-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		4 / 4 LEU A 110
ASP A 133
VAL A 117
THR A 178
 None
 1.00A 3cyxB-1axdA:
undetectable		 3cyxB-1axdA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		4 / 8 ASN A 111
THR A 107
SER A 170
ARG A  16
 None
 1.03A 3kp2A-1axdA:
undetectable
3kp2B-1axdA:
0.0		 3kp2A-1axdA:
24.48
3kp2B-1axdA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 3meeA-1axdA:
undetectable		 3meeA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 3megA-1axdA:
0.0		 3megA-1axdA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		4 / 6 ARG A  16
PRO A  55
GLU A  66
SER A  67
 None
 0.96A 3vlnA-1axdA:
20.3		 3vlnA-1axdA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.49A 4g1qA-1axdA:
0.0		 4g1qA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 4iclA-1axdA:
0.0		 4iclA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 4id5A-1axdA:
0.0		 4id5A-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.46A 4idkA-1axdA:
0.0		 4idkA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.45A 4ifvA-1axdA:
0.0		 4ifvA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.46A 4ifyA-1axdA:
0.0		 4ifyA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 4ig3A-1axdA:
0.0		 4ig3A-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.45A 4kfbA-1axdA:
0.0		 4kfbA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		6 / 11 PHE A 160
ASP A 165
ALA A  93
VAL A  97
ASP A  96
SER A 162
 None
 1.32A 4xnxA-1axdA:
2.3		 4xnxA-1axdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 10 PHE A 160
ALA A  93
VAL A  97
ASP A  96
SER A 162
 None
 1.32A 4xp1A-1axdA:
undetectable		 4xp1A-1axdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.47A 5cymA-1axdA:
0.0		 5cymA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.48A 5cyqA-1axdA:
0.0		 5cyqA-1axdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 11 LEU A 156
GLY A 158
GLU A  91
VAL A  97
ALA A 164
 None
 1.00A 5o96G-1axdA:
undetectable		 5o96G-1axdA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 1axd GLUTATHIONE
S-TRANSFERASE I
(Zea
mays) 		5 / 12 PRO A  55
LEU A   5
VAL A 206
VAL A   9
TYR A  28
 None
 1.46A 6eliA-1axdA:
0.0		 6eliA-1axdA:
15.27