SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1axk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.78A 1c9sI-1axkA:
2.3
1c9sJ-1axkA:
1.1		 1c9sI-1axkA:
11.17
1c9sJ-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1c9sU-1axkA:
1.0
1c9sV-1axkA:
2.0		 1c9sU-1axkA:
11.17
1c9sV-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 GLY A 169
GLY A 190
TRP A 186
VAL A 194
 None
 0.92A 1dbbH-1axkA:
undetectable
1dbbL-1axkA:
0.0		 1dbbH-1axkA:
22.31
1dbbL-1axkA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 7 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.77A 1gtnA-1axkA:
1.1
1gtnK-1axkA:
1.2		 1gtnA-1axkA:
11.17
1gtnK-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.74A 1gtnA-1axkA:
0.9
1gtnB-1axkA:
2.1		 1gtnA-1axkA:
11.17
1gtnB-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.76A 1gtnE-1axkA:
2.1
1gtnF-1axkA:
1.1		 1gtnE-1axkA:
11.17
1gtnF-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1gtnP-1axkA:
0.9
1gtnQ-1axkA:
0.0		 1gtnP-1axkA:
11.17
1gtnQ-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1utdB-1axkA:
1.1
1utdC-1axkA:
1.2		 1utdB-1axkA:
11.17
1utdC-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1utdF-1axkA:
0.8
1utdG-1axkA:
1.0		 1utdF-1axkA:
11.17
1utdG-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1utdI-1axkA:
1.1
1utdJ-1axkA:
2.0		 1utdI-1axkA:
11.17
1utdJ-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.75A 1utdJ-1axkA:
1.1
1utdK-1axkA:
0.9		 1utdJ-1axkA:
11.17
1utdK-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 6 TYR A 236
GLY A 329
TYR A 225
ASN A 219
 None
 1.14A 2g72A-1axkA:
undetectable		 2g72A-1axkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 6 TRP A 100
TYR A  97
TYR A  64
ILE A  48
 None
 1.07A 2pgzD-1axkA:
0.0
2pgzE-1axkA:
0.1		 2pgzD-1axkA:
23.08
2pgzE-1axkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 GLY A 389
ASN A 377
ASN A 379
ILE A  29
GLY A  54
 None
 1.08A 3eeyA-1axkA:
undetectable		 3eeyA-1axkA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 GLY A 389
ASN A 377
ASN A 379
ILE A  29
GLY A  54
 None
 1.08A 3eeyB-1axkA:
undetectable		 3eeyB-1axkA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 GLY A 389
ASN A 377
ASN A 379
ILE A  29
GLY A  54
 None
 1.10A 3eeyH-1axkA:
undetectable		 3eeyH-1axkA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 GLY A 389
ASN A 377
ASN A 379
ILE A  29
GLY A  54
 None
 1.10A 3eeyI-1axkA:
undetectable		 3eeyI-1axkA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 TYR A 225
THR A 223
TYR A 236
GLY A 220
 None
 0.74A 3jusA-1axkA:
0.0		 3jusA-1axkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 TYR A 225
THR A 223
TYR A 236
GLY A 220
 None
 0.74A 3jusA-1axkA:
0.0		 3jusA-1axkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 TYR A 225
THR A 223
TYR A 236
GLY A 220
 None
 0.78A 3jusB-1axkA:
0.0		 3jusB-1axkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 GLY A 226
VAL A 237
ALA A 321
LEU A 316
ILE A 233
 None
 1.00A 3ku1H-1axkA:
undetectable		 3ku1H-1axkA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 4 ASN A 208
SER A 240
LEU A 222
THR A 206
 None
 1.42A 4an2A-1axkA:
undetectable		 4an2A-1axkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 5 GLY A  85
SER A  83
ALA A  82
PHE A  86
 None
 1.04A 4m93B-1axkA:
undetectable
4m93C-1axkA:
undetectable		 4m93B-1axkA:
20.56
4m93C-1axkA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 7 TYR A 221
TYR A 236
LEU A 224
PHE A 302
 None
 1.02A 4yv5A-1axkA:
0.0		 4yv5A-1axkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 7 TYR A 221
TYR A 236
LEU A 224
PHE A 302
 None
 1.08A 4yv5B-1axkA:
undetectable		 4yv5B-1axkA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		3 / 3 THR A 339
HIS A 108
LEU A 106
 None
 0.87A 5axdC-1axkA:
undetectable		 5axdC-1axkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1axk GLUXYN-1
(Bacillus
subtilis) 		3 / 3 PHE A  91
ILE A  50
ASP A 103
 None
 0.68A 5cswA-1axkA:
0.0		 5cswA-1axkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1axk GLUXYN-1
(Bacillus
subtilis) 		3 / 3 PHE A  91
ILE A  50
ASP A 103
 None
 0.64A 5cswB-1axkA:
0.0		 5cswB-1axkA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 12 LEU A 232
THR A 279
ALA A 271
TRP A 165
TYR A 322
 None
 1.49A 5dsgB-1axkA:
undetectable		 5dsgB-1axkA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 8 THR A 247
THR A 266
ARG A 268
GLN A 283
 None
 0.95A 5tzoA-1axkA:
34.6		 5tzoA-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 8 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
 None
 0.53A 5tzoA-1axkA:
34.6		 5tzoA-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		7 / 12 VAL A 193
TRP A 227
TYR A 236
PRO A 272
TRP A 285
TYR A 322
GLY A 329
 None
 0.61A 5tzoA-1axkA:
34.6		 5tzoA-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		6 / 12 VAL A 193
TRP A 227
TYR A 236
TRP A 285
TYR A 322
GLY A 329
 None
 0.61A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		3 / 3 ARG A 268
PRO A 272
TYR A 330
 None
 0.58A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 8 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
 None
 0.44A 5tzoB-1axkA:
34.6		 5tzoB-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		7 / 12 VAL A 193
TRP A 227
TYR A 236
PRO A 272
TRP A 285
TYR A 322
GLY A 329
 None
 0.68A 5tzoC-1axkA:
34.5		 5tzoC-1axkA:
58.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1axk GLUXYN-1
(Bacillus
subtilis) 		5 / 8 TYR A 264
THR A 266
ARG A 268
GLN A 283
TRP A 285
 None
 0.43A 5tzoC-1axkA:
34.5		 5tzoC-1axkA:
58.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 5 GLY A 242
THR A 243
SER A 333
SER A 332
 None
 0.88A 6jmjA-1axkA:
undetectable		 6jmjA-1axkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 7 GLY A 242
THR A 243
SER A 333
SER A 332
 None
 0.85A 6jnhA-1axkA:
undetectable		 6jnhA-1axkA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1axk GLUXYN-1
(Bacillus
subtilis) 		4 / 6 GLY A 242
THR A 243
SER A 333
SER A 332
 None
 0.86A 6jogA-1axkA:
undetectable		 6jogA-1axkA:
16.46