SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1axn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 7 ASP A  71
ILE A  57
ALA A  31
ILE A  32
 None
 0.65A 1n49A-1axnA:
undetectable		 1n49A-1axnA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 5 ASP A 112
GLY A 235
ALA A 243
ILE A 115
 None
 0.80A 2aofA-1axnA:
undetectable		 2aofA-1axnA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 5 ASP A 112
GLY A 235
ALA A 243
ILE A 115
 None
 0.73A 2aohB-1axnA:
undetectable		 2aohB-1axnA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 5 LEU A 158
LEU A 114
MET A 126
THR A 199
 None
 1.41A 2oaxD-1axnA:
0.0		 2oaxD-1axnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 SER A  44
ASP A 311
ASP A  38
 None
 0.72A 2plwA-1axnA:
undetectable		 2plwA-1axnA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 6 ILE A  28
ILE A 314
LEU A  69
MET A  85
 None
 0.87A 3adsA-1axnA:
undetectable		 3adsA-1axnA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 7 ILE A  28
ILE A 314
LEU A  69
MET A  85
 None
 0.94A 3adxA-1axnA:
undetectable		 3adxA-1axnA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 6 SER A 281
LEU A 263
ILE A 288
LEU A  84
 None
 0.86A 3kk6A-1axnA:
0.0		 3kk6A-1axnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 6 SER A 281
LEU A 263
ILE A 288
LEU A  84
 None
 0.89A 3kk6B-1axnA:
0.0		 3kk6B-1axnA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 ILE A 225
VAL A 245
ARG A 249
 None
 0.76A 3p73A-1axnA:
0.0		 3p73A-1axnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 10 ILE A 145
LEU A 100
THR A 149
ILE A 244
THR A 122
 None
 1.00A 3prsA-1axnA:
undetectable		 3prsA-1axnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 LYS A  74
VAL A  86
HIS A  83
 None
 0.86A 3tj7A-1axnA:
undetectable		 3tj7A-1axnA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 HIS A 295
GLU A 257
ASN A 246
 None
 0.88A 4bupB-1axnA:
0.6		 4bupB-1axnA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 7 VAL A  58
LEU A  69
MET A  85
VAL A  86
 None
 0.89A 4e1gB-1axnA:
0.0		 4e1gB-1axnA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 9 LEU A 273
LEU A  88
THR A 315
LEU A 316
ILE A 319
 None
 1.26A 4ubsA-1axnA:
0.0		 4ubsA-1axnA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 11 LEU A 241
GLU A 200
LEU A 202
ALA A 186
LEU A 183
 None
 1.15A 4wg0F-1axnA:
undetectable
4wg0G-1axnA:
undetectable
4wg0H-1axnA:
undetectable		 4wg0F-1axnA:
4.02
4wg0G-1axnA:
4.02
4wg0H-1axnA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 11 ALA A 186
LEU A 183
GLU A 200
LEU A 202
LEU A 241
 None
 1.09A 4wg0G-1axnA:
undetectable
4wg0H-1axnA:
undetectable
4wg0I-1axnA:
undetectable		 4wg0G-1axnA:
4.02
4wg0H-1axnA:
4.02
4wg0I-1axnA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 5 GLU A 282
THR A  12
HIS A  80
LEU A  84
 None
 1.28A 5axaA-1axnA:
undetectable		 5axaA-1axnA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 12 ILE A 182
ILE A 225
THR A 193
ASP A 194
LEU A 241
 None
None
CA  A 353 (-4.9A)
None
None
 1.05A 5e72A-1axnA:
undetectable		 5e72A-1axnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 8 GLN A 125
ALA A 132
GLN A 131
SER A 130
 None
 1.18A 5km8A-1axnA:
undetectable
5km8B-1axnA:
undetectable		 5km8A-1axnA:
20.31
5km8B-1axnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 6 ILE A 225
ALA A 180
LEU A 183
ILE A 201
 None
 0.81A 5mvmB-1axnA:
1.4
5mvmC-1axnA:
1.4		 5mvmB-1axnA:
15.19
5mvmC-1axnA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 1axn ANNEXIN III
(Homo
sapiens) 		5 / 12 GLY A 235
LEU A 118
ASP A 239
PHE A 153
THR A 149
 None
 1.37A 5nknA-1axnA:
undetectable		 5nknA-1axnA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1axn ANNEXIN III
(Homo
sapiens) 		4 / 4 LEU A 118
LEU A 100
SER A 130
ALA A  97
 None
 1.14A 5uunA-1axnA:
0.0		 5uunA-1axnA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 HIS A 295
GLU A 257
ASN A 246
 None
 0.85A 5wbvA-1axnA:
0.0		 5wbvA-1axnA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1axn ANNEXIN III
(Homo
sapiens) 		3 / 3 HIS A 295
GLU A 257
ASN A 246
 None
 0.84A 5wbvB-1axnA:
0.0		 5wbvB-1axnA:
22.35