SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1aye'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 11 HIS A  69
ILE A 194
ASP A 256
GLY A 253
TYR A 206
 ZN  A 400 (-3.2A)
None
None
None
None
 1.47A 1axwB-1ayeA:
0.0		 1axwB-1ayeA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 4 THR A  54
LEU A  32
VAL A  33
LEU A  25
 None
 0.97A 1fbmD-1ayeA:
0.0		 1fbmD-1ayeA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		3 / 3 THR A  54
LEU A  32
LEU A  25
 None
 0.54A 1mz9C-1ayeA:
undetectable		 1mz9C-1ayeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 4 THR A  54
LEU A  32
VAL A  33
LEU A  25
 None
 0.86A 1mz9D-1ayeA:
undetectable		 1mz9D-1ayeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 MET A  93
GLN A  83
VAL A  82
LEU A   4
GLN A 120
 None
 1.16A 1nhzA-1ayeA:
undetectable		 1nhzA-1ayeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 ALA A  66
LEU A  86
GLY A  67
TYR A 116
GLN A 120
 None
 1.14A 1qabF-1ayeA:
0.0		 1qabF-1ayeA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 7 LEU A 201
GLY A 253
ILE A 255
VAL A 246
ILE A 247
 None
 1.46A 2aojB-1ayeA:
undetectable		 2aojB-1ayeA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 7 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 400 (-4.3A)
 1.20A 2c8aA-1ayeA:
undetectable		 2c8aA-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 400 (-4.3A)
 1.26A 2c8aB-1ayeA:
undetectable		 2c8aB-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
ZN  A 400 (-4.3A)
 1.25A 2c8aC-1ayeA:
undetectable		 2c8aC-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 400 (-4.3A)
 1.28A 2c8aD-1ayeA:
undetectable		 2c8aD-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 8 SER A 162
ASP A 163
SER A 164
SER A 157
 None
 1.01A 2cmlB-1ayeA:
undetectable		 2cmlB-1ayeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 8 SER A 162
ASP A 163
SER A 164
SER A 157
 None
 1.04A 2cmlD-1ayeA:
undetectable		 2cmlD-1ayeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
 0.97A 2j2pA-1ayeA:
undetectable
2j2pB-1ayeA:
0.0		 2j2pA-1ayeA:
19.60
2j2pB-1ayeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 ARG A 124
SER A 197
LEU A 280
GLY A 278
 None
 1.02A 2j2pD-1ayeA:
0.1
2j2pF-1ayeA:
0.0		 2j2pD-1ayeA:
19.60
2j2pF-1ayeA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 THR A  75
ALA A  79
LEU A  80
LEU A 107
ILE A 179
 None
 1.11A 2jfaA-1ayeA:
undetectable		 2jfaA-1ayeA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 9 LEU A 107
ILE A 105
ILE A  86
ALA A  79
LEU A  64
 None
 1.19A 2m9qA-1ayeA:
0.0		 2m9qA-1ayeA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 THR A  75
ALA A  79
LEU A  80
LEU A 107
ILE A 179
 None
 1.05A 2qxsA-1ayeA:
undetectable		 2qxsA-1ayeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 THR A  75
ALA A  79
LEU A  80
LEU A 107
ILE A 179
 None
 1.08A 2qxsB-1ayeA:
undetectable		 2qxsB-1ayeA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 8 LEU A 230
LEU A 295
LYS A 298
ALA A 299
 None
 1.01A 2wekA-1ayeA:
undetectable		 2wekA-1ayeA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 7 ILE A  62
TYR A 309
VAL A 189
TYR A 265
 None
 1.35A 2xz5D-1ayeA:
undetectable
2xz5E-1ayeA:
0.0		 2xz5D-1ayeA:
20.70
2xz5E-1ayeA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 5 GLN A 285
PHE A  95
ARG A 124
ARG A 272
 None
 1.42A 3bjwE-1ayeA:
0.0		 3bjwE-1ayeA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 THR A 289
THR A 293
LEU A 195
THR A  78
 None
 0.73A 3deuB-1ayeA:
1.4		 3deuB-1ayeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 9 ALA A 290
VAL A  74
PRO A 282
ALA A 283
ILE A 286
 None
 1.05A 3ektB-1ayeA:
undetectable		 3ektB-1ayeA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 ILE A  18
VAL A 117
MET A  47
PRO A  46
SER A  41
 None
 0.91A 3iw1A-1ayeA:
0.0		 3iw1A-1ayeA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 PHE A  52
MET A  22
THR A  54
ALA A  66
ILE A 193
 None
 1.09A 3nxuB-1ayeA:
undetectable		 3nxuB-1ayeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 ILE A 193
PHE A 269
ILE A  62
ALA A 191
VAL A 222
 None
 1.26A 3s79A-1ayeA:
0.0		 3s79A-1ayeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 5 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.88A 3u8qA-1ayeA:
undetectable		 3u8qA-1ayeA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 5 LEU A 195
LEU A  64
MET A 301
THR A  82
 None
 1.11A 4do3A-1ayeA:
undetectable		 4do3A-1ayeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 6 LEU A 195
LEU A  64
ILE A 105
MET A 301
THR A  82
 None
 1.28A 4do3B-1ayeA:
0.0		 4do3B-1ayeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 THR A 129
GLY A 115
PRO A 113
ASN A 112
 None
 0.86A 4fjpA-1ayeA:
undetectable		 4fjpA-1ayeA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		3 / 3 ARG A  55
ASP A  36
TRP A  38
 None
 0.75A 4xdqA-1ayeA:
undetectable		 4xdqA-1ayeA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 THR A  78
LEU A  80
ALA A  79
LEU A 107
LEU A 297
 None
 1.04A 4xi3C-1ayeA:
undetectable		 4xi3C-1ayeA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 ILE A 105
VAL A 180
THR A  78
LEU A 195
HIS A 196
 None
None
None
None
ZN  A 400 (-3.2A)
 1.27A 5esgA-1ayeA:
0.0		 5esgA-1ayeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		5 / 12 ILE A 193
PHE A 269
ILE A  62
ALA A 191
VAL A 222
 None
 1.25A 5jkvA-1ayeA:
0.0		 5jkvA-1ayeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 5 GLU A  89
TYR A  12
TYR A 116
ARG A 124
 None
 1.36A 5mthH-1ayeA:
0.0
5mthL-1ayeA:
0.0		 5mthH-1ayeA:
22.02
5mthL-1ayeA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 ILE A 194
ASP A 256
GLY A 253
TYR A 206
 None
 0.93A 5x5qE-1ayeA:
0.0		 5x5qE-1ayeA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 ALA A 268
GLY A  67
THR A 111
ILE A 179
 None
 0.90A 6f8cA-1ayeA:
0.0		 6f8cA-1ayeA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 6 TRP A  73
HIS A  69
ASN A 112
GLU A 173
 None
ZN  A 400 (-3.2A)
None
None
 1.25A 6gneA-1ayeA:
2.8		 6gneA-1ayeA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 1aye PROCARBOXYPEPTIDASE
A2
(Homo
sapiens) 		4 / 8 TRP A  73
HIS A  69
ASN A 112
GLU A 173
 None
ZN  A 400 (-3.2A)
None
None
 1.23A 6gneB-1ayeA:
3.2		 6gneB-1ayeA:
21.36