SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b04'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 268
ARG A 272
PHE A 310
 None
 1.22A 1zeaH-1b04A:
undetectable
1zeaL-1b04A:
undetectable		 1zeaH-1b04A:
20.00
1zeaL-1b04A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A  43
TYR A  20
ARG A   9
ALA A  10
GLU A  36
 None
 1.10A 2vppA-1b04A:
undetectable		 2vppA-1b04A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A  43
TYR A  20
ARG A   9
ALA A  10
GLU A  36
 None
 1.11A 2vppB-1b04A:
0.0		 2vppB-1b04A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 9 ARG A 204
THR A 134
VAL A 120
ALA A 199
ALA A 200
 None
 1.28A 3ax7B-1b04A:
0.0		 3ax7B-1b04A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 171
GLY A 117
ALA A 199
PRO A 195
 None
 0.98A 3bgdA-1b04A:
undetectable		 3bgdA-1b04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 164
VAL A 220
TYR A 240
GLY A 222
TYR A 124
 None
 1.48A 4b3oA-1b04A:
0.0		 4b3oA-1b04A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		4 / 6 PHE A 246
GLY A 127
LEU A 164
VAL A 162
 None
 0.77A 4dubB-1b04A:
0.9		 4dubB-1b04A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 213
ASP A 143
ASP A 207
 None
 0.79A 4uckA-1b04A:
undetectable		 4uckA-1b04A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		4 / 5 SER A  83
ARG A 204
GLY A 141
GLU A 142
 None
 1.21A 5btiA-1b04A:
0.0
5btiB-1b04A:
undetectable		 5btiA-1b04A:
22.20
5btiB-1b04A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		4 / 5 SER A  83
ARG A 204
GLY A 141
GLU A 142
 None
 1.13A 5btiC-1b04A:
0.0
5btiD-1b04A:
undetectable		 5btiC-1b04A:
22.20
5btiD-1b04A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 164
VAL A 220
TYR A 240
GLY A 222
TYR A 124
 None
 1.49A 6bsgA-1b04A:
undetectable		 6bsgA-1b04A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		5 / 10 LEU A 164
VAL A 220
TYR A 240
GLY A 222
TYR A 124
 None
 1.49A 6bsjA-1b04A:
undetectable		 6bsjA-1b04A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A  18
PRO A  60
GLN A  62
 None
 0.92A 6jnhA-1b04A:
undetectable		 6jnhA-1b04A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1b04 PROTEIN (DNA LIGASE)
(Geobacillus
stearothermophil
us) 		3 / 3 ASN A  18
PRO A  60
GLN A  62
 None
 0.94A 6jogA-1b04A:
undetectable		 6jogA-1b04A:
18.44