SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 9 THR A  74
LEU A  70
VAL A  39
ILE A  83
VAL A 110
 None
 1.42A 1gebA-1b0aA:
0.0		 1gebA-1b0aA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 4 ASP A  84
LEU A  79
LEU A  82
LEU A  80
 None
 1.40A 1u18A-1b0aA:
undetectable		 1u18A-1b0aA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 7 ALA A 253
TYR A 255
ILE A 256
ILE A   5
 None
 0.91A 1upfB-1b0aA:
4.5		 1upfB-1b0aA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 5 LEU A  86
ASP A  89
ALA A  37
ILE A  92
 None
 0.93A 2aofB-1b0aA:
undetectable		 2aofB-1b0aA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 8 ILE A   5
PHE A 246
GLY A 261
GLY A 262
 None
 0.75A 2qx4A-1b0aA:
4.7
2qx4B-1b0aA:
4.8		 2qx4A-1b0aA:
22.30
2qx4B-1b0aA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 6 ILE A   5
PHE A 246
GLY A 261
GLY A 262
 None
 0.71A 2qx6A-1b0aA:
4.8
2qx6B-1b0aA:
4.8		 2qx6A-1b0aA:
22.30
2qx6B-1b0aA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 8 MET A 175
ALA A 209
THR A 257
LEU A 149
 None
 1.02A 2wx2B-1b0aA:
undetectable		 2wx2B-1b0aA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 12 GLY A  94
VAL A  38
ALA A 278
THR A 275
LEU A 271
 None
 1.24A 3dh0A-1b0aA:
4.5		 3dh0A-1b0aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 5 PRO A 260
VAL A 259
THR A 148
GLY A 145
 None
 1.11A 3elzB-1b0aA:
0.0		 3elzB-1b0aA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 9 ASP A 229
ILE A 228
VAL A 263
GLY A   8
ILE A 155
 None
 0.92A 3s43A-1b0aA:
undetectable		 3s43A-1b0aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 4 GLY A 264
GLY A 261
THR A 257
LEU A 149
 None
 0.93A 3si7C-1b0aA:
0.0
3si7D-1b0aA:
0.0		 3si7C-1b0aA:
21.41
3si7D-1b0aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 9 ILE A 207
ALA A 162
SER A 254
ILE A 228
THR A 186
 None
 1.24A 3tq8A-1b0aA:
undetectable		 3tq8A-1b0aA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 6 CYH A 141
THR A 142
GLY A 122
ASP A 121
 None
 1.22A 3w9tE-1b0aA:
0.0		 3w9tE-1b0aA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 8 VAL A 244
VAL A 245
ILE A 216
ASP A 219
 None
 0.61A 3wzeA-1b0aA:
undetectable		 3wzeA-1b0aA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 10 ILE A 207
ALA A 162
SER A 254
ILE A 228
THR A 186
 None
 1.27A 4g8zX-1b0aA:
undetectable		 4g8zX-1b0aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		6 / 12 VAL A 147
LEU A 150
GLY A 183
ALA A 182
LEU A 181
LEU A 131
 None
 1.39A 4o1zA-1b0aA:
0.0		 4o1zA-1b0aA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 11 ILE A  92
GLY A  35
ALA A  37
LEU A  86
VAL A  39
 None
 1.26A 5hw4B-1b0aA:
undetectable		 5hw4B-1b0aA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 12 ILE A 272
PRO A  34
LEU A 276
GLU A  59
PHE A  63
 None
 1.36A 5k7uA-1b0aA:
undetectable		 5k7uA-1b0aA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 12 LEU A 160
ALA A 162
VAL A 163
ILE A 256
ALA A   3
 None
 1.14A 5n5dB-1b0aA:
5.0		 5n5dB-1b0aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 6 ARG A  66
THR A  85
ASP A  84
LEU A  82
 None
 1.14A 5tdzA-1b0aA:
undetectable		 5tdzA-1b0aA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 10 ILE A 146
ILE A  11
GLY A   8
GLY A 262
LEU A 150
 None
 1.03A 5twjB-1b0aA:
undetectable		 5twjB-1b0aA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 8 LEU A  82
VAL A  41
VAL A 110
LEU A  70
 None
 0.87A 6czmD-1b0aA:
0.0
6czmF-1b0aA:
0.0		 6czmD-1b0aA:
23.14
6czmF-1b0aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		9 / 12 LEU A  96
GLN A  98
ASP A 121
PHE A 123
THR A 142
SER A 168
ILE A 170
VAL A 171
THR A 267
 None
 0.81A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		8 / 12 LEU A  96
GLN A  98
LEU A  99
PRO A 100
ASP A 121
PHE A 123
THR A 142
THR A 267
 None
 0.71A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		6 / 12 LEU A  96
GLN A  98
LEU A  99
PRO A 100
ASP A 121
THR A 267
 None
 1.18A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		9 / 12 LEU A  96
GLN A  98
PRO A 100
ASP A 121
PHE A 123
THR A 142
ILE A 170
VAL A 171
THR A 267
 None
 0.84A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 12 LEU A  99
PRO A 100
ASP A 121
PHE A 123
THR A 142
 None
 0.98A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 5 TYR A  50
LYS A  54
GLN A  98
GLY A 211
 None
 0.79A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		4 / 5 TYR A  50
LYS A  54
GLY A 211
ILE A 232
 None
 0.85A 6debB-1b0aA:
40.9		 6debB-1b0aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)
(Escherichia
coli) 		5 / 12 GLY A  94
LEU A  36
GLY A  35
ASP A 119
ASN A 274
 None
 1.13A 6mhtA-1b0aA:
undetectable		 6mhtA-1b0aA:
23.10