SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2TSR_B_D16B409_1 (THYMIDYLATE SYNTHASE)	1b12	SIGNAL PEPTIDASE I (Escherichia coli)	4 / 8	ARG A 295 ILE A 130 ASP A 280 GLY A 272	None	0.87A	2tsrB-1b12A: 0.0	2tsrB-1b12A: 23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WWS_A_SAMA501_0 (PUTATIVE METHYLTRANSFERASE NSUN6)	1b12	SIGNAL PEPTIDASE I (Escherichia coli)	5 / 12	PRO A 241 ASP A 276 ASP A 280 GLY A 272 LEU A 164	None	1.13A	5wwsA-1b12A: undetectable	5wwsA-1b12A: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FZB_B_SRYB301_1 (STREPTOMYCIN 3''-ADENYLYLTRANSFER ASE)	1b12	SIGNAL PEPTIDASE I (Escherichia coli)	5 / 12	ASP A 245 LEU A 164 ASP A 273 ILE A 237 THR A 239	None	1.44A	6fzbB-1b12A: 0.0	6fzbB-1b12A: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HU9_Q_PCFQ202_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL CYTOCHROME C OXIDASE SUBUNIT 1)	1b12	SIGNAL PEPTIDASE I (Escherichia coli)	4 / 6	TYR A 283 ALA A 259 ARG A 282 ASP A 276	None	1.12A	6hu9m-1b12A: undetectable 6hu9q-1b12A: undetectable	6hu9m-1b12A: 18.94 6hu9q-1b12A: 19.03

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2TSR_B_D16B409_1","THYMIDYLATE SYNTHASE","1b12","SIGNAL PEPTIDASE I","Escherichia coli",4,"ARG A 295;ILE A 130;ASP A 280;GLY A 272","None","0.87A","2tsrB-1b12A:0.0","2tsrB-1b12A:23.17"],["5WWS_A_SAMA501_0","PUTATIVE METHYLTRANSFERASE NSUN6","1b12","SIGNAL PEPTIDASE I","Escherichia coli",5,"PRO A 241;ASP A 276;ASP A 280;GLY A 272;LEU A 164","None","1.13A","5wwsA-1b12A:undetectable","5wwsA-1b12A:18.46"],["6FZB_B_SRYB301_1","STREPTOMYCIN 3''-ADENYLYLTRANSFERASE","1b12","SIGNAL PEPTIDASE I","Escherichia coli",5,"ASP A 245;LEU A 164;ASP A 273;ILE A 237;THR A 239","None","1.44A","6fzbB-1b12A:0.0","6fzbB-1b12A:18.45"],["6HU9_Q_PCFQ202_0","CYTOCHROME C OXIDASE POLYPEPTIDE 5A, MITOCHONDRIAL;CYTOCHROME C OXIDASE SUBUNIT 1","1b12","SIGNAL PEPTIDASE I","Escherichia coli",4,"TYR A 283;ALA A 259;ARG A 282;ASP A 276","None","1.12A","6hu9m-1b12A:undetectable;6hu9q-1b12A:undetectable","6hu9m-1b12A:18.94;6hu9q-1b12A:19.03"]]