SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TKQ_A_DVAA6_0 (MINI-GRAMICIDIN A)	1b1b	PROTEIN (IRON DEPENDENT REGULATOR) (Mycobacterium tuberculosis)	3 / 3	ALA A 99 VAL A 97 TRP A 94	None	0.98A	1tkqA-1b1bA: undetectable	1tkqA-1b1bA: 11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q6O_B_SAMB500_0 (HYPOTHETICAL PROTEIN)	1b1b	PROTEIN (IRON DEPENDENT REGULATOR) (Mycobacterium tuberculosis)	4 / 6	ASP A 88 VAL A 87 PRO A 123 THR A 125	None	1.33A	2q6oB-1b1bA: undetectable	2q6oB-1b1bA: 24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZW2_A_ACTA511_0 (L-PROLYL-[PEPTIDYL-C ARRIER PROTEIN] DEHYDROGENASE)	1b1b	PROTEIN (IRON DEPENDENT REGULATOR) (Mycobacterium tuberculosis)	3 / 3	ARG A 80 ILE A 132 SER A 126	SO4 A 303 (-4.0A) None SO4 A 303 ( 4.9A)	0.85A	5zw2A-1b1bA: 0.0	5zw2A-1b1bA: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZW4_A_SAMA302_1 (PUTATIVE O-METHYLTRANSFERASE YRRM)	1b1b	PROTEIN (IRON DEPENDENT REGULATOR) (Mycobacterium tuberculosis)	4 / 6	GLU A 83 ARG A 84 ARG A 80 ASP A 88	ZN A 301 (-2.6A) None SO4 A 303 (-4.0A) None	1.21A	5zw4A-1b1bA: undetectable	5zw4A-1b1bA: 22.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TKQ_A_DVAA6_0","MINI-GRAMICIDIN A","1b1b","PROTEIN (IRON DEPENDENT REGULATOR)","Mycobacterium tuberculosis",3,"ALA A  99;VAL A  97;TRP A  94","None","0.98A","1tkqA-1b1bA:undetectable","1tkqA-1b1bA:11.11"],["2Q6O_B_SAMB500_0","HYPOTHETICAL PROTEIN","1b1b","PROTEIN (IRON DEPENDENT REGULATOR)","Mycobacterium tuberculosis",4,"ASP A  88;VAL A  87;PRO A 123;THR A 125","None","1.33A","2q6oB-1b1bA:undetectable","2q6oB-1b1bA:24.11"],["5ZW2_A_ACTA511_0","L-PROLYL-[PEPTIDYL-CARRIER PROTEIN] DEHYDROGENASE","1b1b","PROTEIN (IRON DEPENDENT REGULATOR)","Mycobacterium tuberculosis",3,"ARG A  80;ILE A 132;SER A 126","SO4 A 303 (-4.0A);None;SO4 A 303 ( 4.9A)","0.85A","5zw2A-1b1bA:0.0","5zw2A-1b1bA:19.04"],["5ZW4_A_SAMA302_1","PUTATIVE O-METHYLTRANSFERASE YRRM","1b1b","PROTEIN (IRON DEPENDENT REGULATOR)","Mycobacterium tuberculosis",4,"GLU A  83;ARG A  84;ARG A  80;ASP A  88"," ZN A 301 (-2.6A);None;SO4 A 303 (-4.0A);None","1.21A","5zw4A-1b1bA:undetectable","5zw4A-1b1bA:22.62"]]