SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		4 / 7 THR A  28
THR A  79
GLY A 114
TYR A 118
 FMN  A 190 (-3.5A)
FMN  A 190 (-4.0A)
FMN  A 190 (-3.2A)
FMN  A 190 (-3.5A)
 0.88A 1bu5A-1b1cA:
18.0		 1bu5A-1b1cA:
30.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		4 / 7 THR A  30
THR A  79
GLY A 114
TYR A 118
 FMN  A 190 (-3.5A)
FMN  A 190 (-4.0A)
FMN  A 190 (-3.2A)
FMN  A 190 (-3.5A)
 0.74A 1bu5A-1b1cA:
18.0		 1bu5A-1b1cA:
30.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 163
TRP A 164
 None
 1.03A 1r15C-1b1cA:
4.0		 1r15C-1b1cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 163
TRP A 164
 None
 1.04A 1r15F-1b1cA:
4.0		 1r15F-1b1cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 163
TRP A 164
 None
 1.05A 1r15G-1b1cA:
3.9		 1r15G-1b1cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 163
TRP A 164
 None
 1.03A 1r15H-1b1cA:
4.0		 1r15H-1b1cA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 ASP A  58
VAL A  10
PRO A  66
 None
 0.72A 2avvA-1b1cA:
undetectable		 2avvA-1b1cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		6 / 11 HIS A 170
LEU A  65
VAL A 106
GLY A 105
ILE A  68
ALA A  71
 None
 1.31A 2yy8A-1b1cA:
3.0
2yy8B-1b1cA:
undetectable		 2yy8A-1b1cA:
18.01
2yy8B-1b1cA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		5 / 12 ALA A  52
ASN A  19
ILE A  68
GLY A  49
THR A  16
 None
 0.84A 3rukB-1b1cA:
undetectable		 3rukB-1b1cA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		5 / 11 ALA A  52
PHE A  23
ASN A  19
GLY A  49
THR A  16
 None
 0.96A 3rukD-1b1cA:
undetectable		 3rukD-1b1cA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		5 / 9 TRP A  95
THR A  99
LEU A 132
LEU A 135
GLY A 136
 None
 1.42A 4c9kB-1b1cA:
undetectable		 4c9kB-1b1cA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		4 / 5 ASN A 122
GLY A 114
ASP A  41
ASP A 155
 None
FMN  A 190 (-3.2A)
None
None
 1.05A 4n48B-1b1cA:
undetectable		 4n48B-1b1cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		4 / 4 ASN A 122
GLY A 114
ASP A  41
ASP A 155
 None
FMN  A 190 (-3.2A)
None
None
 1.07A 4n49A-1b1cA:
undetectable		 4n49A-1b1cA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		4 / 6 THR A  30
ASN A 122
LEU A 143
GLU A 142
 FMN  A 190 (-3.5A)
None
None
None
 1.14A 4nc3A-1b1cA:
undetectable		 4nc3A-1b1cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		5 / 12 ALA A  52
ASN A  19
ILE A  68
GLY A  49
THR A  16
 None
 0.91A 4nkxB-1b1cA:
undetectable		 4nkxB-1b1cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1b1c PROTEIN
(NADPH-CYTOCHROME
P450 REDUCTASE)
(Homo
sapiens) 		3 / 3 ARG A 160
PHE A  75
LEU A 113
 None
None
FMN  A 190 (-4.2A)
 0.84A 5veuA-1b1cA:
0.0		 5veuA-1b1cA:
17.43