SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 SER A 345
VAL A 392
GLY A 391
LEU A  84
TYR A 171
 None
 1.18A 1a27A-1b25A:
undetectable		 1a27A-1b25A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 PHE A  60
LEU A   9
VAL A 128
VAL A 199
 None
 0.94A 1e7aB-1b25A:
0.1		 1e7aB-1b25A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 SER A 345
VAL A 392
GLY A 391
LEU A  84
TYR A 171
 None
 1.15A 1iolA-1b25A:
undetectable		 1iolA-1b25A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ARG A 355
HIS A 402
 None
 1.15A 1mj2A-1b25A:
undetectable
1mj2B-1b25A:
undetectable		 1mj2A-1b25A:
11.31
1mj2B-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ARG A 355
HIS A 402
 None
 1.12A 1mj2C-1b25A:
undetectable
1mj2D-1b25A:
undetectable		 1mj2C-1b25A:
11.31
1mj2D-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ARG A 355
HIS A 402
 None
 1.13A 1mjoC-1b25A:
undetectable
1mjoD-1b25A:
undetectable		 1mjoC-1b25A:
11.31
1mjoD-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 GLU A 351
ARG A 355
HIS A 402
HIS A 407
ALA A 405
 None
 1.08A 1mjqA-1b25A:
0.1
1mjqB-1b25A:
undetectable		 1mjqA-1b25A:
11.31
1mjqB-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ALA A 396
HIS A 402
 None
 1.13A 1mjqC-1b25A:
undetectable
1mjqD-1b25A:
undetectable		 1mjqC-1b25A:
11.31
1mjqD-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ARG A 355
HIS A 402
 None
 1.01A 1mjqC-1b25A:
undetectable
1mjqD-1b25A:
undetectable		 1mjqC-1b25A:
11.31
1mjqD-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 GLU A 351
ARG A 355
HIS A 402
HIS A 407
ALA A 405
 None
 1.07A 1mjqI-1b25A:
undetectable
1mjqJ-1b25A:
undetectable		 1mjqI-1b25A:
11.31
1mjqJ-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ALA A 396
HIS A 402
 None
 1.13A 1mjqI-1b25A:
undetectable
1mjqJ-1b25A:
undetectable		 1mjqI-1b25A:
11.31
1mjqJ-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 HIS A 407
ALA A 405
GLU A 351
ARG A 355
HIS A 402
 None
 1.01A 1mjqI-1b25A:
undetectable
1mjqJ-1b25A:
undetectable		 1mjqI-1b25A:
11.31
1mjqJ-1b25A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 LEU A 426
ASP A 550
GLY A 593
ARG A 534
 None
 0.89A 1mt1G-1b25A:
0.0
1mt1J-1b25A:
undetectable		 1mt1G-1b25A:
12.02
1mt1J-1b25A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 ARG A 534
LEU A 426
ASP A 550
GLY A 593
 None
 0.91A 1mt1H-1b25A:
0.0
1mt1K-1b25A:
0.0		 1mt1H-1b25A:
13.14
1mt1K-1b25A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 LEU A 426
ASP A 550
GLY A 593
ARG A 534
 None
 0.93A 1n13A-1b25A:
0.0
1n13F-1b25A:
0.0		 1n13A-1b25A:
12.02
1n13F-1b25A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A 534
LEU A 426
ASP A 550
GLY A 593
 None
 0.91A 1n13H-1b25A:
0.0
1n13K-1b25A:
0.0		 1n13H-1b25A:
13.14
1n13K-1b25A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 LEU A 426
ASP A 550
GLY A 593
ARG A 534
 None
 0.91A 1n13G-1b25A:
0.0
1n13J-1b25A:
0.0		 1n13G-1b25A:
12.02
1n13J-1b25A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 ASN A  92
GLY A  74
ASP A  90
ILE A 533
GLY A 483
 PTT  A 800 (-3.5A)
None
None
None
None
 1.13A 1q8jB-1b25A:
undetectable		 1q8jB-1b25A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 THR A  95
LEU A  93
VAL A 174
THR A 141
 None
PTT  A 800 (-4.6A)
None
None
 1.06A 1uyuA-1b25A:
0.0		 1uyuA-1b25A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.79A 1wmqA-1b25A:
0.0		 1wmqA-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.78A 1wmqB-1b25A:
0.0		 1wmqB-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.80A 1wpuA-1b25A:
0.0		 1wpuA-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.80A 1wpuB-1b25A:
0.0		 1wpuB-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.80A 1wrqA-1b25A:
0.0		 1wrqA-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A  35
ILE A 433
GLY A 434
ALA A 435
 None
 0.79A 1wrqB-1b25A:
0.0		 1wrqB-1b25A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A 434
GLY A 410
GLY A  86
VAL A 413
HIS A 407
 None
 0.85A 2b25A-1b25A:
undetectable		 2b25A-1b25A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 LEU A 101
TYR A 106
ILE A 123
ILE A 121
 None
 0.83A 2bu8A-1b25A:
0.0		 2bu8A-1b25A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 ARG A 534
LEU A 426
ASP A 550
GLY A 593
 None
 0.90A 2qqcH-1b25A:
0.0
2qqcK-1b25A:
0.0		 2qqcH-1b25A:
14.88
2qqcK-1b25A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 9 PHE A 263
ILE A 331
ALA A 374
GLY A 318
LEU A 317
 None
 1.27A 2v0mB-1b25A:
0.0		 2v0mB-1b25A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		3 / 3 MET A 335
VAL A 158
GLU A 147
 None
 0.90A 2x9gA-1b25A:
undetectable		 2x9gA-1b25A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 LEU A 509
ILE A  32
ILE A  59
LEU A  76
 None
 0.75A 2xkwB-1b25A:
0.0		 2xkwB-1b25A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.07A 2xz5A-1b25A:
undetectable
2xz5C-1b25A:
0.0		 2xz5A-1b25A:
14.64
2xz5C-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.22A 2xz5A-1b25A:
undetectable
2xz5C-1b25A:
0.0		 2xz5A-1b25A:
14.64
2xz5C-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.07A 2xz5C-1b25A:
0.0
2xz5D-1b25A:
0.0		 2xz5C-1b25A:
14.64
2xz5D-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 ILE A 443
TRP A 441
CYH A 247
TYR A 307
 None
 1.22A 2xz5C-1b25A:
0.0
2xz5D-1b25A:
0.0		 2xz5C-1b25A:
14.64
2xz5D-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 TYR A 262
PHE A 263
ARG A 256
GLY A 261
ILE A 420
 None
 1.31A 2zznB-1b25A:
undetectable		 2zznB-1b25A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 5 ASN A 257
PHE A 258
ALA A 347
GLY A 343
 None
 1.21A 3bcrA-1b25A:
undetectable		 3bcrA-1b25A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 VAL A 169
LEU A 168
LYS A  81
SER A  82
PRO A  83
 None
 1.14A 3bjwB-1b25A:
0.0		 3bjwB-1b25A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 VAL A 169
LEU A 168
LYS A  81
SER A  82
PRO A  83
 None
 1.14A 3bjwE-1b25A:
0.0		 3bjwE-1b25A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 VAL A 169
LEU A 168
LYS A  81
SER A  82
PRO A  83
 None
 1.13A 3bjwF-1b25A:
0.0		 3bjwF-1b25A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 VAL A 169
LEU A 168
LYS A  81
SER A  82
PRO A  83
 None
 1.08A 3bjwH-1b25A:
undetectable		 3bjwH-1b25A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 LEU A 342
GLY A 343
VAL A 413
LEU A 313
LEU A 328
 None
 1.02A 3cjtC-1b25A:
undetectable		 3cjtC-1b25A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 ALA A  97
ILE A 121
LEU A 196
PHE A  60
THR A  95
 None
 1.11A 3fl9B-1b25A:
undetectable		 3fl9B-1b25A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 ALA A  97
ILE A 121
LEU A 196
PHE A  60
THR A  95
 None
 1.08A 3fl9G-1b25A:
undetectable		 3fl9G-1b25A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 9 ALA A  97
ILE A 121
LEU A 196
PHE A  60
THR A  95
 None
 1.11A 3fl9H-1b25A:
undetectable		 3fl9H-1b25A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 ARG A 146
VAL A 174
LEU A 342
ILE A 161
 None
 0.95A 3gp0A-1b25A:
undetectable		 3gp0A-1b25A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		3 / 3 LEU A 426
LEU A 579
ARG A 585
 None
 0.76A 3hcnB-1b25A:
undetectable		 3hcnB-1b25A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 PHE A  31
VAL A 529
ILE A   8
GLY A  33
 None
 0.82A 3hjoA-1b25A:
undetectable		 3hjoA-1b25A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 PHE A  31
VAL A 529
ILE A   8
GLY A  33
 None
 0.83A 3hjoB-1b25A:
0.0		 3hjoB-1b25A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 9 LEU A 218
TYR A 505
PHE A 485
GLY A  73
ILE A 226
 None
 1.30A 3jusB-1b25A:
0.0		 3jusB-1b25A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A   3
ARG A   7
ASP A 125
GLY A 203
ASN A  66
 None
 1.35A 3jzjA-1b25A:
0.0		 3jzjA-1b25A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 9 GLY A  91
GLY A 183
MET A 187
VAL A 190
ILE A 433
 PTT  A 800 (-3.2A)
PTT  A 800 (-3.4A)
None
None
None
 1.49A 3owxA-1b25A:
undetectable		 3owxA-1b25A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 ALA A 490
GLY A  73
ALA A 222
TYR A 223
TYR A 504
 None
 1.44A 3qxyB-1b25A:
0.0
3qxyQ-1b25A:
undetectable		 3qxyB-1b25A:
22.36
3qxyQ-1b25A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A 415
GLY A 314
SER A 315
PHE A 263
ALA A 266
 None
 1.27A 3sueD-1b25A:
undetectable		 3sueD-1b25A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 HIS A 100
GLY A 157
SER A 176
GLY A  73
ASN A  92
 None
None
None
None
PTT  A 800 (-3.5A)
 1.48A 3v3nA-1b25A:
undetectable		 3v3nA-1b25A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 HIS A 100
GLY A 157
SER A 176
GLY A  73
ASN A  92
 None
None
None
None
PTT  A 800 (-3.5A)
 1.48A 3v3nD-1b25A:
0.0		 3v3nD-1b25A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 TRP A 441
CYH A 247
TYR A 307
ILE A 443
 None
 1.03A 4bqtC-1b25A:
0.0
4bqtD-1b25A:
undetectable		 4bqtC-1b25A:
14.64
4bqtD-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 VAL A 199
ALA A  97
LEU A  93
PHE A  60
LEU A  58
 None
None
PTT  A 800 (-4.6A)
None
None
 1.07A 4eckB-1b25A:
undetectable		 4eckB-1b25A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 ASN A 329
VAL A 294
GLU A 304
ARG A 282
 None
None
PTT  A 800 (-3.5A)
None
 1.27A 4mv7A-1b25A:
undetectable		 4mv7A-1b25A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		6 / 12 MET A 241
ILE A 269
VAL A 325
LEU A 328
GLY A 343
LEU A 253
 None
 1.04A 4o1zA-1b25A:
0.0		 4o1zA-1b25A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 ALA A 172
GLY A 186
ILE A 161
GLY A 336
ARG A 380
 None
 1.07A 4obwD-1b25A:
undetectable		 4obwD-1b25A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 LEU A 159
MET A 191
VAL A 190
MET A 187
ILE A 130
 None
 1.35A 4okbA-1b25A:
0.1		 4okbA-1b25A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 GLU A 559
THR A 558
HIS A 407
ASN A 257
 None
 1.27A 4pfjB-1b25A:
undetectable		 4pfjB-1b25A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		3 / 3 LEU A 580
ASP A 577
TYR A 576
 None
 0.67A 4qc6B-1b25A:
0.0		 4qc6B-1b25A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 11 LYS A 195
SER A 129
ILE A 130
LEU A  13
THR A 144
 None
 1.20A 4qi9C-1b25A:
undetectable		 4qi9C-1b25A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A  36
GLY A  34
ILE A  41
ALA A  39
ARG A 587
 None
 1.02A 4qtuB-1b25A:
undetectable		 4qtuB-1b25A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A  36
GLY A  34
ILE A  41
ALA A  39
ARG A 587
 None
 0.95A 4qtuD-1b25A:
undetectable		 4qtuD-1b25A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 THR A 513
ILE A  32
ALA A 490
ILE A 512
PHE A  65
 None
 1.37A 4rp9A-1b25A:
undetectable		 4rp9A-1b25A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 7 LEU A 373
ALA A 352
LEU A 384
ALA A 388
 None
 0.54A 4z90F-1b25A:
0.0
4z90G-1b25A:
0.0
4z90H-1b25A:
0.0
4z90J-1b25A:
0.0		 4z90F-1b25A:
20.50
4z90G-1b25A:
20.50
4z90H-1b25A:
20.50
4z90J-1b25A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 6 ARG A 528
ASP A 527
ARG A 479
GLY A 483
 None
 0.90A 5cdqA-1b25A:
0.0
5cdqC-1b25A:
0.0
5cdqD-1b25A:
undetectable		 5cdqA-1b25A:
23.09
5cdqC-1b25A:
23.09
5cdqD-1b25A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 5 GLY A 300
ARG A 330
MET A 274
MET A 241
 None
 1.33A 5gwkA-1b25A:
0.0		 5gwkA-1b25A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 LYS A 195
SER A 129
ILE A 130
LEU A  13
THR A 144
 None
 1.15A 5hi6A-1b25A:
undetectable		 5hi6A-1b25A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 10 VAL A  77
GLY A  33
LEU A  58
ILE A  41
ALA A  79
 None
 0.96A 5vm8B-1b25A:
undetectable		 5vm8B-1b25A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 10 VAL A  77
GLY A  34
LEU A  58
ILE A  41
ALA A  79
 None
 1.07A 5vm8B-1b25A:
undetectable		 5vm8B-1b25A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A 314
GLY A 318
GLU A 324
VAL A 325
LEU A 328
 None
 0.81A 6ectA-1b25A:
undetectable		 6ectA-1b25A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 12 GLY A 314
GLY A 318
GLU A 324
VAL A 325
LEU A 328
 None
 0.77A 6ecxA-1b25A:
undetectable		 6ecxA-1b25A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		5 / 10 ARG A 534
ALA A 471
LEU A 579
LEU A 580
TYR A 584
 None
 1.41A 6g2pB-1b25A:
0.0		 6g2pB-1b25A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)
(Pyrococcus
furiosus) 		4 / 8 VAL A 344
ASN A 316
ASN A 417
PRO A 254
 None
 1.05A 6hzpA-1b25A:
undetectable		 6hzpA-1b25A:
22.38