SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b3q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 7 LEU A 567
ALA A 612
VAL A 625
VAL A 592
 None
 0.64A 1epbA-1b3qA:
0.0		 1epbA-1b3qA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 8 LEU A 372
ARG A 370
VAL A 380
LEU A 432
 None
 0.95A 1fiqC-1b3qA:
0.0		 1fiqC-1b3qA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 6 LEU A 517
ILE A 300
GLU A 398
ARG A 354
 None
 1.05A 1mt1A-1b3qA:
0.0
1mt1F-1b3qA:
0.0		 1mt1A-1b3qA:
12.16
1mt1F-1b3qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 7 LEU A 517
ILE A 300
GLU A 398
ARG A 354
 None
 1.02A 1n13I-1b3qA:
undetectable
1n13L-1b3qA:
undetectable		 1n13I-1b3qA:
12.16
1n13L-1b3qA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		3 / 3 LYS A 302
ILE A 353
THR A 394
 None
 0.83A 1rx3A-1b3qA:
undetectable		 1rx3A-1b3qA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		5 / 12 ASN A 409
ASP A 412
ASP A 449
ARG A 452
THR A 531
 None
 1.15A 1s14A-1b3qA:
2.8		 1s14A-1b3qA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 5 GLY A 652
PRO A 559
ALA A 546
ILE A 635
 None
 0.92A 2aofA-1b3qA:
undetectable		 2aofA-1b3qA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 8 THR A 531
MET A 521
ILE A 523
ASP A 449
 None
 1.12A 2xytE-1b3qA:
0.0		 2xytE-1b3qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 8 THR A 531
MET A 521
ILE A 523
ASP A 449
 None
 1.05A 2xytH-1b3qA:
0.0		 2xytH-1b3qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 7 THR A 531
MET A 521
ILE A 523
ASP A 449
 None
 1.08A 2xytI-1b3qA:
0.0		 2xytI-1b3qA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		3 / 3 GLY A 414
GLY A 530
GLY A 451
 None
 0.40A 3bogC-1b3qA:
0.0		 3bogC-1b3qA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		3 / 3 GLY A 414
GLY A 530
GLY A 451
 None
 0.36A 3bogD-1b3qA:
0.0		 3bogD-1b3qA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		5 / 12 ILE A 635
ASP A 634
ALA A 546
ASN A 562
ILE A 558
 None
HG  A 998 (-3.3A)
None
None
None
 1.23A 3ddyA-1b3qA:
undetectable		 3ddyA-1b3qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		5 / 12 ASN A 409
ASP A 412
ASP A 449
ARG A 452
THR A 531
 None
 1.14A 3lpsA-1b3qA:
2.6		 3lpsA-1b3qA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 7 LEU A 406
ASN A 409
GLY A 453
ILE A 454
 None
 0.86A 3spkB-1b3qA:
0.0		 3spkB-1b3qA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 5 SER A 435
ASP A 449
ASP A 412
ILE A 411
 None
 1.30A 3uj7B-1b3qA:
undetectable		 3uj7B-1b3qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		3 / 3 ARG A 385
ARG A 437
ILE A 433
 None
 0.87A 4b7qA-1b3qA:
undetectable		 4b7qA-1b3qA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		3 / 3 LYS A 302
ILE A 353
THR A 394
 None
 0.87A 4gh8A-1b3qA:
undetectable		 4gh8A-1b3qA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		5 / 12 GLY A 414
ALA A 410
GLY A 451
LEU A 432
GLY A 530
 None
 0.96A 4o3fA-1b3qA:
undetectable		 4o3fA-1b3qA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1b3q PROTEIN (CHEMOTAXIS
PROTEIN CHEA)
(Thermotoga
maritima) 		4 / 6 ILE A 415
ARG A 421
ILE A 429
GLU A 379
 None
 1.15A 4zzcA-1b3qA:
0.0
4zzcB-1b3qA:
0.0		 4zzcA-1b3qA:
22.41
4zzcB-1b3qA:
22.41