SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 218
LEU A 211
ILE A   4
GLY A   5
 None
 0.97A 1cqeA-1b43A:
0.0		 1cqeA-1b43A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 218
LEU A 211
ILE A   4
GLY A   5
 None
 0.98A 1cqeB-1b43A:
0.0		 1cqeB-1b43A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		4 / 8 ASP A 174
GLU A 151
GLY A 152
ASP A 235
 None
 0.89A 1m4iA-1b43A:
0.0		 1m4iA-1b43A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 218
LEU A 211
ILE A   4
GLY A   5
 None
 0.98A 2aylB-1b43A:
0.0		 2aylB-1b43A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		3 / 3 ASN A 186
TYR A 173
SER A 170
 None
 0.94A 2gvcB-1b43A:
0.0		 2gvcB-1b43A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 GLY A 239
GLU A 114
GLN A 121
ASP A 235
ASP A 174
 None
 1.44A 2vqyA-1b43A:
0.0		 2vqyA-1b43A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 9 VAL A 253
SER A 256
LEU A 231
ILE A 230
ILE A   8
 None
 1.18A 3cv9A-1b43A:
undetectable		 3cv9A-1b43A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 ILE A 252
ILE A 244
GLY A 239
PRO A   3
LEU A 260
 None
 1.14A 3em0B-1b43A:
undetectable		 3em0B-1b43A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 218
LEU A 211
ILE A   4
GLY A   5
 None
 1.09A 3kk6A-1b43A:
0.4		 3kk6A-1b43A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 VAL A 214
LEU A 218
LEU A 211
ILE A   4
GLY A   5
 None
 1.09A 3kk6B-1b43A:
0.0		 3kk6B-1b43A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		3 / 3 ARG A 125
GLU A  81
ARG A  97
 None
 0.86A 4mwvA-1b43A:
undetectable		 4mwvA-1b43A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		3 / 3 ASP A 235
ASN A 237
SER A 175
 None
 0.86A 4obwA-1b43A:
undetectable		 4obwA-1b43A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1b43 PROTEIN (FEN-1)
(Pyrococcus
furiosus) 		5 / 12 GLY A 243
GLY A   5
ILE A   4
GLY A 239
GLY A 240
 None
 0.94A 5koxA-1b43A:
undetectable		 5koxA-1b43A:
22.63