SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_RALB600_1 (ESTROGEN RECEPTOR)	1b4a	ARGININE REPRESSOR (Geobacillus stearothermophil us)	5 / 12	LEU A 94 LEU A 93 ILE A 122 LEU A 80 LEU A 149	None	1.21A	1errB-1b4aA: undetectable	1errB-1b4aA: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q8H_A_TF4A438_1 ([PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1)	1b4a	ARGININE REPRESSOR (Geobacillus stearothermophil us)	4 / 6	LEU A 25 ILE A 45 ARG A 6 ILE A 10	None	1.01A	2q8hA-1b4aA: undetectable	2q8hA-1b4aA: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_C_ACHC1210_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1b4a	ARGININE REPRESSOR (Geobacillus stearothermophil us)	4 / 8	ILE A 106 VAL A 108 CYH A 128 CYH A 123	None	1.02A	2xz5A-1b4aA: 0.0 2xz5C-1b4aA: undetectable	2xz5A-1b4aA: 21.00 2xz5C-1b4aA: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_D_ACHD1210_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1b4a	ARGININE REPRESSOR (Geobacillus stearothermophil us)	4 / 8	ILE A 106 VAL A 108 CYH A 128 CYH A 123	None	1.03A	2xz5C-1b4aA: undetectable 2xz5D-1b4aA: 0.0	2xz5C-1b4aA: 21.00 2xz5D-1b4aA: 21.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_B_RALB600_1","ESTROGEN RECEPTOR","1b4a","ARGININE REPRESSOR","Geobacillus stearothermophilus",5,"LEU A  94;LEU A  93;ILE A 122;LEU A  80;LEU A 149","None","1.21A","1errB-1b4aA:undetectable","1errB-1b4aA:20.16"],["2Q8H_A_TF4A438_1","[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1","1b4a","ARGININE REPRESSOR","Geobacillus stearothermophilus",4,"LEU A  25;ILE A  45;ARG A   6;ILE A  10","None","1.01A","2q8hA-1b4aA:undetectable","2q8hA-1b4aA:18.28"],["2XZ5_C_ACHC1210_0","SOLUBLE ACETYLCHOLINE RECEPTOR","1b4a","ARGININE REPRESSOR","Geobacillus stearothermophilus",4,"ILE A 106;VAL A 108;CYH A 128;CYH A 123","None","1.02A","2xz5A-1b4aA:0.0;2xz5C-1b4aA:undetectable","2xz5A-1b4aA:21.00;2xz5C-1b4aA:21.00"],["2XZ5_D_ACHD1210_0","SOLUBLE ACETYLCHOLINE RECEPTOR","1b4a","ARGININE REPRESSOR","Geobacillus stearothermophilus",4,"ILE A 106;VAL A 108;CYH A 128;CYH A 123","None","1.03A","2xz5C-1b4aA:undetectable;2xz5D-1b4aA:0.0","2xz5C-1b4aA:21.00;2xz5D-1b4aA:21.00"]]