SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 THR A  78
ALA A 159
ALA A 154
GLN A 150
ILE A 162
 None
 1.10A 1likA-1b4eA:
undetectable		 1likA-1b4eA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 9 GLU A 237
GLY A 240
SER A 233
SER A 191
THR A 194
 None
 1.38A 1m4gB-1b4eA:
0.3		 1m4gB-1b4eA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.95A 1muiA-1b4eA:
undetectable		 1muiA-1b4eA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.90A 1rl8A-1b4eA:
undetectable		 1rl8A-1b4eA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 11 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.88A 2b60B-1b4eA:
undetectable		 2b60B-1b4eA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.86A 2f80B-1b4eA:
undetectable		 2f80B-1b4eA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.85A 2f81A-1b4eA:
undetectable		 2f81A-1b4eA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 8 GLU A 123
PHE A 204
VAL A  53
TYR A 312
 None
SHF  A 407 (-4.0A)
None
SHF  A 407 (-4.8A)
 1.12A 2fl5E-1b4eA:
undetectable
2fl5F-1b4eA:
undetectable		 2fl5E-1b4eA:
21.21
2fl5F-1b4eA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 9 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.95A 2idwB-1b4eA:
undetectable		 2idwB-1b4eA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 ALA A 157
ALA A 155
THR A 187
MET A  77
ILE A 114
 None
 1.22A 2jjpA-1b4eA:
0.0		 2jjpA-1b4eA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.94A 2rkgB-1b4eA:
undetectable		 2rkgB-1b4eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 8 ALA A 157
LEU A  98
CYH A 106
ILE A 105
VAL A  37
 None
 1.22A 2uxpA-1b4eA:
0.0		 2uxpA-1b4eA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.82A 3cywA-1b4eA:
undetectable		 3cywA-1b4eA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.87A 3cywB-1b4eA:
undetectable		 3cywB-1b4eA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 11 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.83A 3ektC-1b4eA:
undetectable		 3ektC-1b4eA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 11 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.82A 3ektD-1b4eA:
undetectable		 3ektD-1b4eA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.93A 3ekwB-1b4eA:
undetectable		 3ekwB-1b4eA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 8 GLY A 305
ALA A 306
ASP A 307
ILE A 301
 None
 0.64A 3el0A-1b4eA:
undetectable		 3el0A-1b4eA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 11 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.97A 3el1A-1b4eA:
undetectable		 3el1A-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		3 / 3 MET A 168
MET A 190
PHE A 121
 None
 1.18A 3gn8A-1b4eA:
0.0		 3gn8A-1b4eA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.93A 3jvyA-1b4eA:
undetectable		 3jvyA-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.90A 3jvyB-1b4eA:
undetectable		 3jvyB-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.87A 3lzsA-1b4eA:
undetectable		 3lzsA-1b4eA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.81A 3lzsB-1b4eA:
undetectable		 3lzsB-1b4eA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.84A 3lzuA-1b4eA:
undetectable		 3lzuA-1b4eA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.83A 3lzuB-1b4eA:
undetectable		 3lzuB-1b4eA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.92A 3ndtD-1b4eA:
undetectable		 3ndtD-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.91A 3ndwA-1b4eA:
undetectable		 3ndwA-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.91A 3ndxA-1b4eA:
undetectable		 3ndxA-1b4eA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 LEU A  26
GLU A 319
ALA A 318
ASP A  30
LEU A  28
 GOL  A 409 ( 4.7A)
None
None
None
None
 1.38A 3ou6D-1b4eA:
undetectable		 3ou6D-1b4eA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 5 ASN A  29
ASP A 307
GLU A 264
SER A  27
 None
 1.21A 3p2kC-1b4eA:
undetectable		 3p2kC-1b4eA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 5 VAL A 246
ILE A 301
MET A 278
ARG A 226
 None
None
GOL  A 408 ( 4.2A)
SO4  A 402 (-4.5A)
 1.21A 3pyyB-1b4eA:
undetectable		 3pyyB-1b4eA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 7 LEU A  28
SER A 311
LEU A  33
VAL A  53
 None
 0.79A 3r9vA-1b4eA:
0.0
3r9vB-1b4eA:
0.0		 3r9vA-1b4eA:
23.39
3r9vB-1b4eA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 8 GLY A 158
ALA A 159
ASP A 160
ILE A 105
 None
 0.65A 3so9A-1b4eA:
undetectable		 3so9A-1b4eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 7 GLY A 158
ALA A 159
ASP A 160
ILE A 105
 None
 0.62A 3t3cA-1b4eA:
undetectable		 3t3cA-1b4eA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.84A 3tkwA-1b4eA:
undetectable		 3tkwA-1b4eA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.85A 3ttpA-1b4eA:
0.0		 3ttpA-1b4eA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.83A 3ttpB-1b4eA:
undetectable		 3ttpB-1b4eA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 SER A  82
GLY A  97
ALA A 100
CYH A 122
CYH A 120
 None
None
None
ZN  A 405 (-2.3A)
ZN  A 405 (-2.1A)
 1.49A 4bupB-1b4eA:
undetectable		 4bupB-1b4eA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.93A 4hlaA-1b4eA:
undetectable		 4hlaA-1b4eA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 5 VAL A  99
ARG A 101
MET A 102
GLU A  58
 None
 1.26A 4hojA-1b4eA:
0.0		 4hojA-1b4eA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 11 GLY A 158
ALA A 159
ASP A 160
ILE A  35
THR A 119
 None
 0.75A 4l1aA-1b4eA:
undetectable		 4l1aA-1b4eA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.86A 4ll3B-1b4eA:
undetectable		 4ll3B-1b4eA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 10 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.87A 4ll3A-1b4eA:
undetectable		 4ll3A-1b4eA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 GLY A 305
ALA A 306
ASP A 307
ILE A 255
ILE A 301
 None
 0.79A 4njvA-1b4eA:
undetectable		 4njvA-1b4eA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 7 TYR A 276
VAL A 294
ILE A 322
LEU A  33
 None
 1.23A 4xo7B-1b4eA:
10.5		 4xo7B-1b4eA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 5 ALA A 269
ALA A 249
ILE A 301
LEU A 298
 None
 0.72A 5jncD-1b4eA:
0.0		 5jncD-1b4eA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 ASP A  86
GLY A  89
ASN A 146
LEU A 147
ALA A 166
 None
 1.14A 5kc4E-1b4eA:
0.0		 5kc4E-1b4eA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		4 / 7 GLY A 158
ALA A 159
ASP A 160
ILE A 105
 None
 0.64A 5kqyB-1b4eA:
undetectable		 5kqyB-1b4eA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 SER A  82
GLY A  97
ALA A 100
CYH A 122
CYH A 120
 None
None
None
ZN  A 405 (-2.3A)
ZN  A 405 (-2.1A)
 1.44A 5wbvA-1b4eA:
0.0		 5wbvA-1b4eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 12 SER A  82
GLY A  97
ALA A 100
CYH A 122
CYH A 120
 None
None
None
ZN  A 405 (-2.3A)
ZN  A 405 (-2.1A)
 1.44A 5wbvB-1b4eA:
undetectable		 5wbvB-1b4eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		3 / 3 HIS A  83
HIS A  84
ARG A 101
 None
ZN  A 404 (-3.2A)
None
 1.13A 6b58A-1b4eA:
undetectable		 6b58A-1b4eA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)
(Escherichia
coli) 		5 / 9 SER A 117
VAL A 153
ALA A 156
VAL A  99
GLY A 158
 None
GOL  A 410 ( 4.5A)
GOL  A 410 (-3.5A)
None
None
 1.22A 6bklA-1b4eA:
undetectable
6bklB-1b4eA:
undetectable
6bklC-1b4eA:
undetectable
6bklD-1b4eA:
undetectable		 6bklA-1b4eA:
6.19
6bklB-1b4eA:
6.19
6bklC-1b4eA:
6.19
6bklD-1b4eA:
6.19