SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 5 ASN L   1
THR L  97
MET L   4
GLN L  90
 None
 1.46A 1xmuA-1b4jL:
undetectable		 1xmuA-1b4jL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 5 ASN L   1
THR L  97
MET L   4
GLN L  90
 None
 1.48A 1xmuB-1b4jL:
undetectable		 1xmuB-1b4jL:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-1b4jL:
undetectable		 2aojA-1b4jL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 7 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.79A 2aojB-1b4jL:
0.0		 2aojB-1b4jL:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 7 ILE L 106
TYR L  12
TYR L 140
GLU L 165
 None
 1.16A 2qebA-1b4jL:
undetectable		 2qebA-1b4jL:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 7 ILE L 106
TYR L  12
TYR L 140
GLU L 165
 None
 1.16A 2qebB-1b4jL:
undetectable		 2qebB-1b4jL:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 1b4j ANTIBODY
(Homo
sapiens) 		5 / 11 ILE L 117
ALA L 193
PHE L 209
VAL L 132
THR L 206
 None
 1.27A 2w3aA-1b4jL:
undetectable		 2w3aA-1b4jL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 6 ILE L   2
GLU L  27
ALA L  25
ASN L  28
 None
 0.92A 3pgyA-1b4jL:
undetectable
3pgyB-1b4jL:
undetectable		 3pgyA-1b4jL:
20.30
3pgyB-1b4jL:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1b4j ANTIBODY
(Homo
sapiens) 		3 / 3 ARG L 142
GLN L 166
GLU L 165
 None
 0.91A 4tvtA-1b4jL:
0.0		 4tvtA-1b4jL:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 7 TYR L  32
SER L  34
TYR L  36
PHE L  96
 None
 0.96A 5aclA-1b4jL:
17.4		 5aclA-1b4jL:
26.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 7 TYR L  32
SER L  34
TYR L  36
TYR L  49
 None
 0.78A 5aclA-1b4jL:
17.4		 5aclA-1b4jL:
26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 8 SER L  34
TYR L  36
GLY L  89
PHE L  98
 None
 0.28A 5albL-1b4jL:
15.9		 5albL-1b4jL:
44.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 1b4j ANTIBODY
(Homo
sapiens) 		4 / 8 SER L  34
TYR L  36
GLY L  89
PHE L  98
 None
 0.35A 5alcL-1b4jL:
15.5		 5alcL-1b4jL:
43.81