SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		4 / 6 LEU A 158
LEU A  19
ILE A  75
GLU A 100
 None
 0.93A 1mt1A-1b4pA:
undetectable
1mt1F-1b4pA:
undetectable		 1mt1A-1b4pA:
16.58
1mt1F-1b4pA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		4 / 6 ILE A  75
GLU A 100
LEU A 158
LEU A  19
 None
 0.93A 1mt1B-1b4pA:
0.0
1mt1C-1b4pA:
undetectable		 1mt1B-1b4pA:
19.82
1mt1C-1b4pA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 THR A 106
LEU A 110
VAL A 113
 None
 0.47A 1mz9E-1b4pA:
undetectable		 1mz9E-1b4pA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 ARG A 107
ARG A  10
PRO A  15
 None
 0.87A 2wljA-1b4pA:
0.0		 2wljA-1b4pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyC-1b4pA:
undetectable		 3eeyC-1b4pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyD-1b4pA:
undetectable		 3eeyD-1b4pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 ASN A  73
ASP A 161
GLN A 165
 None
 0.82A 3eeyE-1b4pA:
undetectable		 3eeyE-1b4pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		4 / 7 GLN A 144
LEU A 141
SER A 138
GLU A 139
 None
 1.09A 4zphA-1b4pA:
0.0
4zphB-1b4pA:
0.0		 4zphA-1b4pA:
20.64
4zphB-1b4pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		3 / 3 ILE A 207
MET A 197
ASP A 161
 None
 0.77A 5h2uA-1b4pA:
undetectable		 5h2uA-1b4pA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		4 / 6 ASP A 161
HIS A  14
ILE A  16
TYR A   6
 None
 1.28A 5ih0A-1b4pA:
0.0		 5ih0A-1b4pA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)
(Rattus
norvegicus) 		5 / 11 ILE A  16
LEU A 158
LEU A  79
ALA A  80
LEU A  12
 None
None
None
None
GPS  A 218 (-4.3A)
 1.24A 5ji0A-1b4pA:
undetectable		 5ji0A-1b4pA:
23.97