SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 142
GLY A  85
GLY A 138
ASP A 125
HIS A  71
 None
None
None
None
ZN  A 155 ( 3.2A)
 1.25A 1ffyA-1b4tA:
undetectable		 1ffyA-1b4tA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  12
LEU A   7
VAL A  17
ALA A  11
GLY A  44
 None
 0.99A 2vmyA-1b4tA:
undetectable		 2vmyA-1b4tA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		4 / 5 HIS A  46
HIS A  63
VAL A 118
HIS A 120
 CU  A 154 ( 3.0A)
ZN  A 155 (-3.0A)
None
CU  A 154 (-3.3A)
 0.32A 2wkoF-1b4tA:
29.8		 2wkoF-1b4tA:
52.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 138
SER A 134
ASP A  76
ASP A 124
 None
 0.84A 3pwwA-1b4tA:
undetectable		 3pwwA-1b4tA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		5 / 8 ALA A 121
PRO A 144
GLY A 122
ALA A 140
GLY A  44
 None
 1.37A 4zjzB-1b4tA:
undetectable		 4zjzB-1b4tA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		4 / 5 SER A  14
VAL A  13
GLY A  36
ALA A  35
 None
 1.08A 5k50A-1b4tA:
0.0		 5k50A-1b4tA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1b4t PROTEIN (CU/ZN
SUPEROXIDE
DISMUTASE)
(Saccharomyces
cerevisiae) 		3 / 3 HIS A  63
ASP A  83
HIS A  71
 ZN  A 155 (-3.0A)
ZN  A 155 ( 2.3A)
ZN  A 155 ( 3.2A)
 0.76A 5n1tW-1b4tA:
2.4		 5n1tW-1b4tA:
19.30