SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 9 PHE A  47
ASP A 171
GLY A 175
ASN A 178
TYR A 218
 None
None
DCM  A 300 (-3.5A)
None
DCM  A 300 (-4.6A)
 1.49A 1i00B-1b5dA:
18.0		 1i00B-1b5dA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 6 ASN A 170
LEU A 215
TRP A 210
PHE A  41
 DCM  A 300 (-3.9A)
None
None
None
 1.20A 1ru9H-1b5dA:
undetectable
1ru9L-1b5dA:
undetectable		 1ru9H-1b5dA:
20.82
1ru9L-1b5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 6 ASN A 170
LEU A 215
TRP A 210
PHE A  41
 DCM  A 300 (-3.9A)
None
None
None
 1.19A 1rukH-1b5dA:
undetectable
1rukL-1b5dA:
undetectable		 1rukH-1b5dA:
20.82
1rukL-1b5dA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 7 TRP A 182
TYR A 154
TYR A 129
GLY A  97
 None
 0.90A 2ha4B-1b5dA:
undetectable		 2ha4B-1b5dA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 8 ASP A 193
SER A 192
ASP A 188
TRP A 182
 None
 0.92A 3havA-1b5dA:
undetectable		 3havA-1b5dA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.80A 3k2hA-1b5dA:
0.0		 3k2hA-1b5dA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.77A 3k2hB-1b5dA:
0.0		 3k2hB-1b5dA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 1.00A 3nrrA-1b5dA:
6.4		 3nrrA-1b5dA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.91A 4foxD-1b5dA:
18.8		 4foxD-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 11 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.99A 4foxF-1b5dA:
18.9		 4foxF-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 11 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.91A 4foxH-1b5dA:
19.0		 4foxH-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.86A 4fqsA-1b5dA:
18.9		 4fqsA-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.86A 4fqsB-1b5dA:
18.9		 4fqsB-1b5dA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 5 ILE A  34
LEU A  15
ASP A 171
GLU A  35
 None
 1.05A 4nkxB-1b5dA:
0.0		 4nkxB-1b5dA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 ILE A 100
VAL A 165
GLY A 125
THR A 149
LEU A 190
 None
 1.18A 5byjA-1b5dA:
undetectable		 5byjA-1b5dA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 7 ILE A  37
HIS A  14
LEU A  15
ALA A  18
 None
 0.92A 5hrqE-1b5dA:
undetectable
5hrqF-1b5dA:
undetectable
5hrqJ-1b5dA:
undetectable		 5hrqE-1b5dA:
9.35
5hrqF-1b5dA:
7.76
5hrqJ-1b5dA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 12 GLU A  60
TRP A  82
ASP A 171
GLY A 175
TYR A 218
 None
None
None
DCM  A 300 (-3.5A)
DCM  A 300 (-4.6A)
 0.85A 5j7wD-1b5dA:
18.1		 5j7wD-1b5dA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		5 / 10 PHE A  47
ASP A 171
GLY A 175
ASN A 178
TYR A 218
 None
None
DCM  A 300 (-3.5A)
None
DCM  A 300 (-4.6A)
 1.45A 5x66D-1b5dA:
17.7		 5x66D-1b5dA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1b5d PROTEIN
(DEOXYCYTIDYLATE
HYDROXYMETHYLASE)
(Escherichia
virus
T4) 		4 / 5 ARG A 177
GLY A 175
ASN A 170
ASP A 171
 None
DCM  A 300 (-3.5A)
DCM  A 300 (-3.9A)
None
 1.34A 6dwjB-1b5dA:
0.0
6dwjD-1b5dA:
0.0		 6dwjB-1b5dA:
19.09
6dwjD-1b5dA:
19.09