SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b5l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 4 THR A  79
LEU A  82
LEU A  89
GLN A  92
 None
 0.88A 1fbmA-1b5lA:
0.0		 1fbmA-1b5lA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 8 LEU A  82
PHE A  68
PHE A 124
LEU A  38
 None
 0.99A 1wrlC-1b5lA:
undetectable
1wrlD-1b5lA:
undetectable		 1wrlC-1b5lA:
20.24
1wrlD-1b5lA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 6 LEU A  82
LEU A  17
LEU A  18
LEU A  89
 None
 0.82A 2ab2A-1b5lA:
undetectable		 2ab2A-1b5lA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		5 / 10 ALA A 151
GLN A  90
LEU A  93
ASN A  66
LEU A  61
 None
 1.18A 2xn6A-1b5lA:
0.2
2xn6B-1b5lA:
undetectable		 2xn6A-1b5lA:
19.60
2xn6B-1b5lA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 7 ILE A 127
LEU A  67
PHE A 124
THR A 153
 None
 1.04A 3ag2N-1b5lA:
2.6
3ag2W-1b5lA:
0.0		 3ag2N-1b5lA:
15.18
3ag2W-1b5lA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		3 / 3 ARG A  20
LEU A  24
THR A  79
 SO4  A 202 (-2.8A)
None
None
 0.69A 3oxcA-1b5lA:
undetectable		 3oxcA-1b5lA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 8 ARG A  12
ASN A  14
GLY A  88
THR A 156
 SO4  A 201 (-2.8A)
None
None
None
 0.55A 4eyrB-1b5lA:
undetectable		 4eyrB-1b5lA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		5 / 9 THR A 156
LEU A 152
ALA A  11
LEU A  17
LEU A  61
 None
 1.43A 4ltwA-1b5lA:
undetectable		 4ltwA-1b5lA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		5 / 9 ALA A 151
GLN A  90
LEU A  93
ASN A  66
LEU A  61
 None
 1.20A 4x30A-1b5lA:
0.7		 4x30A-1b5lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		4 / 6 ILE A 127
LEU A  67
PHE A 124
THR A 153
 None
 1.06A 5b1aN-1b5lA:
3.3
5b1aW-1b5lA:
0.0		 5b1aN-1b5lA:
15.18
5b1aW-1b5lA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1b5l INTERFERON TAU
(Komagataella
pastoris) 		3 / 3 ALA A  11
ASN A  14
LEU A  15
 None
 0.52A 5i1nC-1b5lA:
0.0		 5i1nC-1b5lA:
13.66