SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 8 ARG A  67
VAL A 136
ILE A  92
LEU A  89
 None
 0.90A 1igxA-1b5tA:
0.0		 1igxA-1b5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 9 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 1utdA-1b5tA:
undetectable
1utdK-1b5tA:
undetectable		 1utdA-1b5tA:
18.80
1utdK-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 6 SER A  57
LEU A 117
ILE A 181
HIS A 273
 None
FAD  A 395 (-4.0A)
FAD  A 395 ( 4.0A)
None
 0.93A 1yajF-1b5tA:
1.2		 1yajF-1b5tA:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZP4_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 9 ASP A 120
GLN A 183
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
 0.29A 1zp4A-1b5tA:
42.7		 1zp4A-1b5tA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZP4_B_C2FB996_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		6 / 10 ASP A 120
GLN A 183
SER A 215
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
None
 0.35A 1zp4B-1b5tA:
43.6		 1zp4B-1b5tA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		6 / 10 ASP A 120
GLN A 183
SER A 215
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
None
 0.32A 1zp4C-1b5tA:
43.8		 1zp4C-1b5tA:
99.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 ASP A 120
THR A 227
TYR A 275
LEU A 277
ARG A 279
 FAD  A 395 (-3.9A)
None
None
None
None
 1.15A 1zp4C-1b5tA:
43.8		 1zp4C-1b5tA:
99.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 6 ILE A 286
ARG A 293
ILE A  23
PHE A 272
 None
 1.15A 2q72A-1b5tA:
0.0		 2q72A-1b5tA:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APT_B_ACTB311_0
(METHYLENETETRAHYDROF
OLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		6 / 9 GLU A  28
HIS A  88
ALA A 150
ILE A 181
HIS A 273
TYR A 275
 FAD  A 395 ( 4.3A)
FAD  A 395 (-3.7A)
FAD  A 395 (-3.4A)
FAD  A 395 ( 4.0A)
None
None
 0.46A 3aptB-1b5tA:
29.4		 3aptB-1b5tA:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		7 / 12 GLN A 183
LEU A 212
SER A 215
ASN A 216
THR A 227
TYR A 275
ARG A 279
 FAD  A 395 ( 4.4A)
None
None
None
None
None
None
 0.72A 3fsuA-1b5tA:
43.6		 3fsuA-1b5tA:
98.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		8 / 12 THR A  59
GLN A 183
LEU A 212
SER A 215
ASN A 216
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.7A)
FAD  A 395 ( 4.4A)
None
None
None
None
None
None
 0.39A 3fsuA-1b5tA:
43.6		 3fsuA-1b5tA:
98.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 11 GLN A 183
SER A 215
THR A 227
TYR A 275
ARG A 279
 FAD  A 395 ( 4.4A)
None
None
None
None
 0.78A 3fsuE-1b5tA:
42.2		 3fsuE-1b5tA:
98.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		7 / 11 THR A  59
ASP A 120
GLN A 183
SER A 215
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.7A)
FAD  A 395 (-3.9A)
FAD  A 395 ( 4.4A)
None
None
None
None
 0.40A 3fsuE-1b5tA:
42.2		 3fsuE-1b5tA:
98.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 7 VAL A  25
VAL A 269
ILE A 211
ARG A 293
 None
 1.22A 3ms9B-1b5tA:
undetectable		 3ms9B-1b5tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 8 ALA A  94
GLU A  98
ASP A 105
ILE A 102
 None
 0.91A 4kttB-1b5tA:
0.0		 4kttB-1b5tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 8 ALA A  94
GLU A  98
ASP A 105
ILE A 102
 None
 0.87A 4kttD-1b5tA:
0.0		 4kttD-1b5tA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 5 HIS A  88
VAL A  58
GLU A  28
VAL A 115
 FAD  A 395 (-3.7A)
None
FAD  A 395 ( 4.3A)
None
 0.99A 4p6vB-1b5tA:
0.0
4p6vE-1b5tA:
undetectable		 4p6vB-1b5tA:
21.98
4p6vE-1b5tA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 7 ASP A  46
ILE A  45
GLY A  76
TRP A  42
 None
 0.86A 4zxiA-1b5tA:
undetectable		 4zxiA-1b5tA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 9 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5eeuA-1b5tA:
undetectable
5eeuB-1b5tA:
undetectable		 5eeuA-1b5tA:
18.80
5eeuB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.14A 5eevA-1b5tA:
undetectable
5eevB-1b5tA:
undetectable		 5eevA-1b5tA:
18.80
5eevB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5eewA-1b5tA:
undetectable
5eewB-1b5tA:
undetectable		 5eewA-1b5tA:
18.80
5eewB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5eexA-1b5tA:
undetectable
5eexB-1b5tA:
undetectable		 5eexA-1b5tA:
18.80
5eexB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5eeyA-1b5tA:
undetectable
5eeyB-1b5tA:
undetectable		 5eeyA-1b5tA:
18.80
5eeyB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.14A 5eezA-1b5tA:
undetectable
5eezB-1b5tA:
undetectable		 5eezA-1b5tA:
18.80
5eezB-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5ef0A-1b5tA:
undetectable
5ef0B-1b5tA:
undetectable		 5ef0A-1b5tA:
18.80
5ef0B-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5ef1A-1b5tA:
undetectable
5ef1B-1b5tA:
undetectable		 5ef1A-1b5tA:
18.80
5ef1B-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.15A 5ef2A-1b5tA:
undetectable
5ef2B-1b5tA:
undetectable		 5ef2A-1b5tA:
18.80
5ef2B-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 10 GLY A 119
ALA A  62
HIS A  88
THR A  90
ILE A  92
 FAD  A 395 (-3.1A)
None
FAD  A 395 (-3.7A)
FAD  A 395 ( 4.2A)
None
 1.14A 5ef3A-1b5tA:
undetectable
5ef3B-1b5tA:
undetectable		 5ef3A-1b5tA:
18.80
5ef3B-1b5tA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		3 / 3 ILE A 208
PRO A 209
ILE A 181
 None
None
FAD  A 395 ( 4.0A)
 0.38A 5hw8F-1b5tA:
0.0		 5hw8F-1b5tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		3 / 3 TYR A 275
TYR A 152
GLN A 183
 None
FAD  A 395 (-4.2A)
FAD  A 395 ( 4.4A)
 1.00A 5jsdA-1b5tA:
0.0
5jsdB-1b5tA:
0.0		 5jsdA-1b5tA:
16.74
5jsdB-1b5tA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		3 / 3 TYR A 275
TYR A 152
GLN A 183
 None
FAD  A 395 (-4.2A)
FAD  A 395 ( 4.4A)
 0.99A 5jsdB-1b5tA:
0.0
5jsdC-1b5tA:
0.0		 5jsdB-1b5tA:
16.74
5jsdC-1b5tA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 8 GLU A  28
GLY A 210
GLN A 183
THR A 182
 FAD  A 395 ( 4.3A)
None
FAD  A 395 ( 4.4A)
None
 1.00A 5sxtB-1b5tA:
undetectable		 5sxtB-1b5tA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		4 / 8 GLU A  28
GLY A 210
GLN A 183
THR A 182
 FAD  A 395 ( 4.3A)
None
FAD  A 395 ( 4.4A)
None
 1.04A 5syjA-1b5tA:
0.0		 5syjA-1b5tA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)
(Escherichia
coli) 		5 / 12 GLY A  61
SER A  72
PHE A  30
GLU A  28
VAL A  58
 None
None
None
FAD  A 395 ( 4.3A)
None
 0.94A 6ectA-1b5tA:
undetectable		 6ectA-1b5tA:
20.74