SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b63'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 ASP A  36
ASP A  58
ILE A  63
ASP A  66
THR A 143
 None
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
ANP  A 380 (-3.7A)
 0.97A 1kijA-1b63A:
19.2		 1kijA-1b63A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 ASN A  33
ASP A  58
ILE A  63
ASP A  66
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
ANP  A 380 (-3.7A)
 0.94A 1kijB-1b63A:
19.4		 1kijB-1b63A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		6 / 12 ASN A  33
SER A  34
ASP A  36
ASP A  58
ASP A  66
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
None
ANP  A 380 (-3.7A)
 0.61A 1s14A-1b63A:
14.4		 1s14A-1b63A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 ASN A  33
SER A  34
ASP A  36
ASP A  58
ASP A  66
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
None
 0.65A 1s14B-1b63A:
14.4		 1s14B-1b63A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 1b63 MUTL
(Escherichia
coli) 		4 / 7 TYR A 152
GLN A  13
PHE A 151
ARG A 158
 None
 1.37A 2qmqA-1b63A:
0.0		 2qmqA-1b63A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1b63 MUTL
(Escherichia
coli) 		4 / 7 LEU A 110
ARG A  57
SER A  78
GLY A  60
 None
None
ANP  A 380 (-2.7A)
None
 1.06A 3hcrB-1b63A:
undetectable		 3hcrB-1b63A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		6 / 12 ASN A  33
SER A  34
ASP A  36
ASP A  58
ASP A  66
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
None
ANP  A 380 (-3.7A)
 0.61A 3lpsA-1b63A:
19.1		 3lpsA-1b63A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 1b63 MUTL
(Escherichia
coli) 		4 / 5 ILE A  54
PRO A  23
LYS A  52
GLY A  50
 None
 1.06A 3tkdB-1b63A:
undetectable		 3tkdB-1b63A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 1b63 MUTL
(Escherichia
coli) 		4 / 5 ILE A  54
PRO A  23
LYS A  52
GLY A  50
 None
 1.05A 3tkdA-1b63A:
undetectable		 3tkdA-1b63A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1b63 MUTL
(Escherichia
coli) 		4 / 8 ILE A  56
ASP A  43
ILE A  42
GLY A  38
 None
 0.79A 4ac9C-1b63A:
undetectable		 4ac9C-1b63A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 GLY A  50
LEU A  53
ILE A  44
VAL A  27
LEU A  30
 None
 1.05A 4fr0A-1b63A:
undetectable		 4fr0A-1b63A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1b63 MUTL
(Escherichia
coli) 		4 / 6 MET A 263
ILE A 187
ILE A  42
VAL A 185
 None
 0.96A 4olmA-1b63A:
undetectable		 4olmA-1b63A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1b63 MUTL
(Escherichia
coli) 		5 / 11 ASN A  33
SER A  34
ASP A  36
ASP A  58
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
ANP  A 380 (-3.7A)
 0.26A 4urnA-1b63A:
14.3		 4urnA-1b63A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1b63 MUTL
(Escherichia
coli) 		5 / 11 ASN A  33
SER A  34
ASP A  36
ASP A  58
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
ANP  A 380 (-3.7A)
 0.29A 4urnB-1b63A:
14.9		 4urnB-1b63A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1b63 MUTL
(Escherichia
coli) 		5 / 11 ASN A  33
SER A  34
ASP A  36
ASP A  58
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
None
ANP  A 380 (-3.6A)
ANP  A 380 (-3.7A)
 0.28A 4urnC-1b63A:
14.4		 4urnC-1b63A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 ASN A  33
SER A  34
ASP A  58
ILE A  63
ASP A  66
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
 0.93A 4uroA-1b63A:
15.0		 4uroA-1b63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		5 / 12 ASN A  33
SER A  34
ASP A  58
ILE A  63
ASP A  66
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
 1.00A 4uroB-1b63A:
14.9		 4uroB-1b63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 1b63 MUTL
(Escherichia
coli) 		6 / 12 ASN A  33
SER A  34
ASP A  58
ILE A  63
ASP A  66
THR A 143
 MG  A 701 ( 2.5A)
ANP  A 380 ( 3.8A)
ANP  A 380 (-3.6A)
ANP  A 380 (-4.5A)
None
ANP  A 380 (-3.7A)
 0.85A 4uroD-1b63A:
14.9		 4uroD-1b63A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1b63 MUTL
(Escherichia
coli) 		4 / 8 GLY A  62
THR A 143
LEU A 110
LEU A  72
 ANP  A 380 (-4.1A)
ANP  A 380 (-3.7A)
None
None
 0.74A 5hs1A-1b63A:
undetectable		 5hs1A-1b63A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1b63 MUTL
(Escherichia
coli) 		3 / 3 VAL A 301
GLU A  29
GLU A  32
 EDO  A 901 (-4.4A)
ANP  A 380 ( 4.6A)
EDO  A 902 (-3.6A)
 0.73A 5jsdB-1b63A:
0.0
5jsdC-1b63A:
0.0		 5jsdB-1b63A:
19.40
5jsdC-1b63A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1b63 MUTL
(Escherichia
coli) 		5 / 10 ILE A  56
ILE A  54
ILE A 171
ILE A 175
ILE A 174
 None
 1.02A 5murE-1b63A:
0.0		 5murE-1b63A:
13.68