SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		4 / 8 ASP A  93
SER A 104
TYR A  52
HIS A  48
 None
None
None
ZN  A 401 ( 3.4A)
 1.38A 2bteD-1b66A:
undetectable		 2bteD-1b66A:
8.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_A_H4BA1003_1
(HYPOTHETICAL PROTEIN
PH0634)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		7 / 10 HIS A  23
HIS A  48
HIS A  50
THR A 105
THR A 106
GLU A 107
GLU A 133
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
BIO  A 700 (-4.3A)
BIO  A 700 (-3.7A)
BIO  A 700 (-3.0A)
BIO  A 700 ( 2.7A)
 0.62A 2dttA-1b66A:
16.1
2dttC-1b66A:
16.0		 2dttA-1b66A:
31.43
2dttC-1b66A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		5 / 10 HIS A  48
THR A 105
THR A 106
GLU A 107
GLU A 133
 ZN  A 401 ( 3.4A)
BIO  A 700 (-4.3A)
BIO  A 700 (-3.7A)
BIO  A 700 (-3.0A)
BIO  A 700 ( 2.7A)
 0.70A 2dttA-1b66A:
16.1
2dttB-1b66A:
15.5		 2dttA-1b66A:
31.43
2dttB-1b66A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		7 / 10 HIS A  23
HIS A  48
HIS A  50
THR A 105
THR A 106
GLU A 107
GLU A 133
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
BIO  A 700 (-4.3A)
BIO  A 700 (-3.7A)
BIO  A 700 (-3.0A)
BIO  A 700 ( 2.7A)
 0.71A 2dttD-1b66A:
16.2
2dttF-1b66A:
16.0		 2dttD-1b66A:
31.43
2dttF-1b66A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		7 / 11 HIS A  23
HIS A  48
HIS A  50
THR A 105
THR A 106
GLU A 107
GLU A 133
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
BIO  A 700 (-4.3A)
BIO  A 700 (-3.7A)
BIO  A 700 (-3.0A)
BIO  A 700 ( 2.7A)
 0.73A 2dttD-1b66A:
16.2
2dttE-1b66A:
15.5		 2dttD-1b66A:
31.43
2dttE-1b66A:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		5 / 9 HIS A  50
THR A 105
THR A 106
GLU A 107
GLU A 133
 ZN  A 401 ( 3.4A)
BIO  A 700 (-4.3A)
BIO  A 700 (-3.7A)
BIO  A 700 (-3.0A)
BIO  A 700 ( 2.7A)
 0.54A 2dttE-1b66A:
15.5
2dttF-1b66A:
16.0		 2dttE-1b66A:
31.43
2dttF-1b66A:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		5 / 12 ALA A  82
GLU A  81
LEU A 120
MET A  70
LEU A 126
 None
 1.16A 3hm1A-1b66A:
undetectable		 3hm1A-1b66A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		4 / 7 PHE A  19
VAL A 131
ILE A 113
SER A 104
 None
 0.83A 3pglA-1b66A:
undetectable		 3pglA-1b66A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.65A 5qglA-1b66A:
0.0		 5qglA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.67A 5qguA-1b66A:
0.0		 5qguA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.67A 5qgvA-1b66A:
0.0		 5qgvA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.65A 5qgwA-1b66A:
0.0		 5qgwA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.66A 5qgxA-1b66A:
0.0		 5qgxA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.67A 5qgyA-1b66A:
0.0		 5qgyA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.66A 5qgzA-1b66A:
0.0		 5qgzA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.65A 5qh0A-1b66A:
0.0		 5qh0A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.68A 5qh1A-1b66A:
0.0		 5qh1A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.65A 5qh2A-1b66A:
0.0		 5qh2A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.67A 5qh3A-1b66A:
0.0		 5qh3A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.69A 5qh4A-1b66A:
0.0		 5qh4A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.69A 5qh9A-1b66A:
0.0		 5qh9A-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.62A 5qhaA-1b66A:
0.0		 5qhaA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.68A 5qhcA-1b66A:
0.0		 5qhcA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.69A 5qheA-1b66A:
0.0		 5qheA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.68A 5qhfA-1b66A:
0.0		 5qhfA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 VAL A  56
VAL A 129
GLN A 118
 None
 0.68A 5qhhA-1b66A:
0.0		 5qhhA-1b66A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		5 / 9 ALA A  82
GLU A  81
LEU A 120
MET A  70
LEU A 126
 None
 1.27A 5wgqA-1b66A:
undetectable		 5wgqA-1b66A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 HIS A  23
HIS A  50
HIS A  48
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
 0.59A 5zrdA-1b66A:
undetectable		 5zrdA-1b66A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1b66 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE
(Rattus
rattus) 		3 / 3 HIS A  48
HIS A  23
HIS A  50
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.4A)
 0.57A 5zrdA-1b66A:
undetectable		 5zrdA-1b66A:
15.20