SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 LEU A 179
VAL A 229
CYH A 227
GLY A 160
 None
 1.07A 1jlfA-1b6rA:
undetectable
1jlfB-1b6rA:
undetectable		 1jlfA-1b6rA:
19.76
1jlfB-1b6rA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ALA A 167
VAL A 165
GLY A 166
ALA A 254
HIS A 248
 None
 0.93A 1kxhA-1b6rA:
undetectable		 1kxhA-1b6rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 PRO A 241
ILE A 266
GLY A 221
TYR A 219
 None
 1.12A 2jkjD-1b6rA:
0.0		 2jkjD-1b6rA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 PRO A 241
ILE A 266
GLY A 221
TYR A 219
 None
 1.13A 2jkjF-1b6rA:
0.0		 2jkjF-1b6rA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 GLY A  31
GLY A  10
GLY A   8
 None
 0.40A 3bogC-1b6rA:
0.0		 3bogC-1b6rA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 11 VAL A 281
THR A 191
GLN A 185
GLU A 342
SER A 345
 None
 1.49A 3kp5A-1b6rA:
undetectable		 3kp5A-1b6rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 THR A 191
LEU A 183
GLN A 185
GLU A 342
SER A 345
 None
 1.44A 4ejwA-1b6rA:
0.0		 4ejwA-1b6rA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ARG A 190
GLY A 187
SER A 288
VAL A 309
VAL A 315
 None
 1.32A 4ffwA-1b6rA:
undetectable		 4ffwA-1b6rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ARG A 190
GLY A 187
SER A 288
VAL A 309
VAL A 315
 None
 1.34A 4ffwB-1b6rA:
undetectable		 4ffwB-1b6rA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 SER A 246
THR A 250
VAL A 222
PHE A 176
 None
 1.06A 4wnvD-1b6rA:
undetectable		 4wnvD-1b6rA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 LEU A 210
ALA A 224
LEU A 164
VAL A 243
 None
 1.20A 5cr1A-1b6rA:
0.0		 5cr1A-1b6rA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ILE A 213
ILE A  76
MET A 225
 None
 0.50A 5i9yA-1b6rA:
undetectable		 5i9yA-1b6rA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 LEU A 335
ASN A 252
LEU A 328
 None
 0.69A 6exiA-1b6rA:
1.4		 6exiA-1b6rA:
12.61