SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		5 / 11 ASP A 193
SER A 192
SER A 191
GLY A 103
THR A 102
 None
 1.36A 1jr1A-1b6uA:
undetectable		 1jr1A-1b6uA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 163
PHE A 164
LEU A 166
 None
 0.59A 2zi9A-1b6uA:
undetectable		 2zi9A-1b6uA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A  62
HIS A  55
LEU A  26
PHE A  34
LEU A  49
 None
 1.26A 3bxoA-1b6uA:
undetectable		 3bxoA-1b6uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		5 / 9 ASP A 193
SER A 192
SER A 191
GLY A 103
THR A 102
 None
 1.27A 4fxsA-1b6uA:
undetectable		 4fxsA-1b6uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A  97
LEU A  49
ASN A  63
 None
 0.63A 4otwA-1b6uA:
undetectable		 4otwA-1b6uA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens) 		5 / 8 LEU A 166
GLY A 167
VAL A 124
ALA A 112
GLY A 172
 None
 1.22A 4zauA-1b6uA:
undetectable		 4zauA-1b6uA:
20.90