SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 5 SER A 205
SER A 207
VAL A  67
PHE A  90
 None
 1.35A 1oipA-1b74A:
1.0		 1oipA-1b74A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 ASP A  33
ILE A  48
VAL A  89
 None
 0.68A 2avvD-1b74A:
0.0		 2avvD-1b74A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 ALA A 248
GLY A  56
GLU A  84
ALA A  55
LEU A  81
 None
 1.10A 2plwA-1b74A:
undetectable		 2plwA-1b74A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 9 ALA A  75
VAL A  92
GLY A 113
VAL A  97
ILE A  93
 None
 0.95A 2q5kA-1b74A:
undetectable		 2q5kA-1b74A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 11 ALA A  75
VAL A  92
GLY A 113
VAL A  97
ILE A  93
 None
 0.91A 2qhcA-1b74A:
undetectable		 2qhcA-1b74A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 7 PHE A   6
ALA A  77
LEU A  52
ALA A  55
 None
 1.18A 2vcvA-1b74A:
0.9		 2vcvA-1b74A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 6 PHE A   6
LEU A  78
LEU A  52
ALA A  55
 None
 0.90A 2vcvB-1b74A:
2.2		 2vcvB-1b74A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 6 PHE A   6
LEU A  78
LEU A  52
ALA A  55
 None
 0.96A 2vcvK-1b74A:
2.0		 2vcvK-1b74A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 ALA A 116
ILE A  41
PRO A 144
PHE A 142
PRO A 182
 None
 1.02A 3cl9A-1b74A:
undetectable		 3cl9A-1b74A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 TYR A  30
LEU A 220
VAL A 245
LEU A 239
ILE A 238
 None
 1.11A 3ijdA-1b74A:
undetectable		 3ijdA-1b74A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 TYR A  30
LEU A 220
VAL A 245
LEU A 239
ILE A 238
 None
 1.10A 3ijdB-1b74A:
0.0		 3ijdB-1b74A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 GLY A  96
GLU A  99
GLY A 110
VAL A 197
ALA A 132
 None
 1.00A 3qowA-1b74A:
2.8		 3qowA-1b74A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 7 GLY A   9
ASP A  33
GLY A  32
VAL A  37
 None
 0.89A 4c5nA-1b74A:
5.5		 4c5nA-1b74A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.62A 4k8cA-1b74A:
3.6		 4k8cA-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.63A 4kahA-1b74A:
4.2		 4kahA-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.63A 4kahB-1b74A:
3.7		 4kahB-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.62A 4kanA-1b74A:
3.7		 4kanA-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.61A 4kanB-1b74A:
3.3		 4kanB-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.63A 4kbeA-1b74A:
4.2		 4kbeA-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.64A 4kbeB-1b74A:
4.1		 4kbeB-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.59A 4lbgA-1b74A:
3.7		 4lbgA-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		3 / 3 SER A 205
TYR A  23
PRO A  95
 None
 0.61A 4lbgB-1b74A:
3.7		 4lbgB-1b74A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 8 VAL A  92
GLY A 113
VAL A  97
ILE A  93
 None
 0.74A 4ll3A-1b74A:
undetectable		 4ll3A-1b74A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		6 / 10 ASP A   7
LEU A 234
ILE A 235
LEU A 231
LEU A  16
PHE A 224
 None
 1.42A 4odoA-1b74A:
undetectable		 4odoA-1b74A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		6 / 10 ASP A   7
LEU A 234
ILE A 235
LEU A 231
LEU A  16
PHE A 224
 None
 1.45A 4odoB-1b74A:
undetectable		 4odoB-1b74A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 10 ASP A   7
LEU A 234
ILE A 235
LEU A 231
PHE A 224
 None
 1.06A 4odoC-1b74A:
undetectable		 4odoC-1b74A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 11 ASP A   7
LEU A 234
ILE A 235
LEU A 231
PHE A 224
 None
 0.94A 4odrA-1b74A:
undetectable
4odrB-1b74A:
undetectable		 4odrA-1b74A:
19.69
4odrB-1b74A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		4 / 6 ARG A  20
GLY A 216
ASP A  27
ASP A 214
 None
 1.30A 5hp1A-1b74A:
undetectable		 5hp1A-1b74A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 ILE A 175
TYR A 123
THR A  14
ALA A 122
SER A 207
 None
 1.09A 5iwuA-1b74A:
undetectable		 5iwuA-1b74A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1b74 GLUTAMATE RACEMASE
(Aquifex
pyrophilus) 		5 / 12 LEU A  58
LEU A  16
GLY A  12
ILE A  19
ALA A  18
 None
 1.17A 6qxsD-1b74A:
0.0		 6qxsD-1b74A:
24.53