SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b7e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		5 / 12 ALA A 261
ARG A 322
GLU A 285
LEU A 300
ILE A 316
 None
 1.18A 1d1gB-1b7eA:
undetectable		 1d1gB-1b7eA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		3 / 3 SER A 369
ARG A 138
GLN A 391
 None
 0.95A 2xnrA-1b7eA:
undetectable		 2xnrA-1b7eA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		3 / 3 GLU A 326
ASP A 188
TYR A 319
 None
 0.79A 2yvlB-1b7eA:
2.2		 2yvlB-1b7eA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		4 / 8 GLU A 161
VAL A 209
CYH A 187
ARG A 189
 None
 1.19A 3b9lA-1b7eA:
3.6		 3b9lA-1b7eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		4 / 5 LEU A 456
GLN A 403
LEU A 405
GLU A 401
 None
TPT  A 480 (-4.0A)
None
None
 1.15A 3h5gA-1b7eA:
undetectable
3h5gB-1b7eA:
undetectable		 3h5gA-1b7eA:
7.10
3h5gB-1b7eA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		4 / 5 GLN A 365
THR A 139
GLU A 327
HIS A 329
 None
 1.26A 3n58A-1b7eA:
undetectable		 3n58A-1b7eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		5 / 8 GLY A 447
GLY A 335
GLU A 454
LEU A 356
VAL A 359
 None
 1.07A 4fgzA-1b7eA:
undetectable		 4fgzA-1b7eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		5 / 8 GLY A 447
GLY A 335
GLU A 454
LEU A 356
VAL A 359
 None
 1.07A 4fgzB-1b7eA:
undetectable		 4fgzB-1b7eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		4 / 8 GLY A 442
THR A 441
THR A 371
ARG A 367
 None
 0.88A 4k87A-1b7eA:
undetectable		 4k87A-1b7eA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		5 / 11 ARG A 431
ALA A 428
LEU A 432
GLY A 433
ALA A 465
 None
 1.10A 4l6v1-1b7eA:
undetectable
4l6v6-1b7eA:
1.4		 4l6v1-1b7eA:
20.44
4l6v6-1b7eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		5 / 12 PHE A 207
LEU A 299
VAL A 282
VAL A 306
LEU A 201
 None
 1.14A 5x24A-1b7eA:
undetectable		 5x24A-1b7eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		3 / 3 ARG A  75
ILE A  74
SER A 354
 None
 0.84A 5zw2A-1b7eA:
0.0		 5zw2A-1b7eA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1b7e PROTEIN (TRANSPOSASE
INHIBITOR PROTEIN
FROM TN5)
(Escherichia
coli) 		3 / 3 LEU A 301
ASN A 276
LEU A 201
 None
 0.62A 6exiA-1b7eA:
undetectable		 6exiA-1b7eA:
11.50