SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		4 / 8 GLN A 282
GLN A 226
ILE A 222
SER A 281
 None
 1.12A 2xz5B-1b7fA:
0.0
2xz5E-1b7fA:
0.0		 2xz5B-1b7fA:
20.09
2xz5E-1b7fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		5 / 12 LEU A 272
VAL A 257
VAL A 215
LEU A 218
ILE A 222
 None
 0.88A 3gwxB-1b7fA:
undetectable		 3gwxB-1b7fA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		4 / 6 GLN A 282
GLN A 226
ILE A 222
SER A 281
 None
 1.03A 3peoG-1b7fA:
0.0		 3peoG-1b7fA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		3 / 3 THR A 216
SER A 285
ARG A 287
 U  P   3 ( 3.9A)
None
G  P   4 ( 3.6A)
 0.80A 3phnA-1b7fA:
0.0		 3phnA-1b7fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		4 / 6 ILE A 242
VAL A 215
PRO A 219
ALA A 255
 None
 0.68A 5cu6A-1b7fA:
undetectable		 5cu6A-1b7fA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		4 / 7 ILE A 242
VAL A 215
PRO A 219
ALA A 255
 None
 0.73A 5ospA-1b7fA:
undetectable		 5ospA-1b7fA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1b7f PROTEIN (SXL-LETHAL
PROTEIN)
(Drosophila
melanogaster) 		4 / 5 LEU A 196
TYR A 131
LYS A 194
LEU A 132
 None
U  P   6 ( 3.7A)
U  P   7 ( 3.8A)
None
 1.34A 5weaA-1b7fA:
3.2		 5weaA-1b7fA:
11.70