SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 ARG O 135
SER O 118
VAL O 137
ASN O  87
 SO4  O 611 ( 4.1A)
None
None
None
 1.23A 1hwkA-1b7gO:
undetectable		 1hwkA-1b7gO:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 ARG O 135
SER O 118
VAL O 137
ASN O  87
 SO4  O 611 ( 4.1A)
None
None
None
 1.25A 1hwkC-1b7gO:
undetectable		 1hwkC-1b7gO:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 ARG O  15
ARG O  46
ILE O  21
GLY O   8
VAL O 305
 None
 1.39A 2nyrB-1b7gO:
4.9		 2nyrB-1b7gO:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 THR O 328
SER O 324
GLU O 307
ALA O 121
 None
 0.98A 2v32A-1b7gO:
undetectable
2v32B-1b7gO:
undetectable		 2v32A-1b7gO:
21.36
2v32B-1b7gO:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 THR O 328
SER O 324
GLU O 307
ALA O 121
 None
 0.97A 2v32A-1b7gO:
undetectable
2v32B-1b7gO:
undetectable		 2v32A-1b7gO:
21.36
2v32B-1b7gO:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 THR O 328
SER O 324
GLU O 307
ALA O 121
 None
 0.91A 2v41G-1b7gO:
undetectable
2v41H-1b7gO:
undetectable		 2v41G-1b7gO:
21.36
2v41H-1b7gO:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 TYR O  51
ALA O  40
ALA O  43
LEU O  28
 None
 1.02A 2wx2B-1b7gO:
undetectable		 2wx2B-1b7gO:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 8 LYS O 172
ARG O 166
GLU O  39
GLU O 173
 SO4  O 610 (-2.6A)
SO4  O 603 ( 3.3A)
SO4  O 610 ( 4.3A)
SO4  O 610 (-4.2A)
 1.40A 3dh0A-1b7gO:
4.7		 3dh0A-1b7gO:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 6 GLY O   8
ASP O  73
ASP O  83
GLU O  72
 None
 1.05A 3vywC-1b7gO:
undetectable		 3vywC-1b7gO:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 9 GLU O 307
ILE O 105
ALA O 128
ALA O 314
ILE O 134
 None
 1.08A 4lbgB-1b7gO:
6.7		 4lbgB-1b7gO:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 8 ALA O  43
VAL O  31
GLY O  10
VAL O  52
ILE O  50
 None
None
SO4  O 610 ( 3.8A)
None
None
 1.26A 4ll3A-1b7gO:
0.0		 4ll3A-1b7gO:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 7 ASP O 196
THR O 141
SER O 191
HIS O 192
 None
None
SO4  O 607 (-4.8A)
SO4  O 601 (-3.8A)
 1.19A 4o4dA-1b7gO:
0.0		 4o4dA-1b7gO:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 LEU O 248
LEU O 237
ILE O 236
ILE O 223
ILE O 225
 None
 0.88A 4odrA-1b7gO:
undetectable
4odrB-1b7gO:
undetectable		 4odrA-1b7gO:
15.63
4odrB-1b7gO:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		3 / 3 ASN O  87
PHE O 106
TYR O  93
 None
 0.73A 4u15A-1b7gO:
undetectable		 4u15A-1b7gO:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 ALA O  32
ASN O   7
GLU O  72
TYR O  93
THR O  34
 None
None
None
None
SO4  O 605 (-4.0A)
 1.33A 4xqeA-1b7gO:
10.9		 4xqeA-1b7gO:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 ALA O  32
ASN O   7
GLU O  72
TYR O  93
THR O  34
 None
None
None
None
SO4  O 605 (-4.0A)
 1.33A 4xqeB-1b7gO:
10.7		 4xqeB-1b7gO:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 ALA O  32
ASN O   7
GLU O  72
TYR O  93
THR O  34
 None
None
None
None
SO4  O 605 (-4.0A)
 1.34A 4xrgB-1b7gO:
10.9		 4xrgB-1b7gO:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		4 / 5 ARG O 135
SER O 118
SER O 199
SER O 138
 SO4  O 611 ( 4.1A)
None
None
SO4  O 601 ( 2.8A)
 1.20A 5hswA-1b7gO:
0.0		 5hswA-1b7gO:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		3 / 3 ASP O 196
ASN O 140
PHE O 106
 None
SO4  O 601 ( 3.8A)
None
 0.71A 5jglB-1b7gO:
undetectable		 5jglB-1b7gO:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		5 / 12 ALA O  43
GLY O  13
GLY O  10
VAL O  52
ILE O  50
 None
None
SO4  O 610 ( 3.8A)
None
None
 0.80A 6dj1A-1b7gO:
undetectable		 6dj1A-1b7gO:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)
(Sulfolobus
solfataricus) 		3 / 3 VAL O 157
GLU O 158
ILE O 225
 None
 0.63A 6f7lB-1b7gO:
4.3		 6f7lB-1b7gO:
20.79