SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b89'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		4 / 8 LEU A1423
PHE A1391
GLY A1389
TYR A1404
 None
 0.74A 1fapB-1b89A:
undetectable		 1fapB-1b89A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		5 / 12 LEU A1430
LEU A1445
VAL A1442
TYR A1438
LEU A1419
 None
 1.29A 1s9pB-1b89A:
undetectable		 1s9pB-1b89A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		4 / 6 PHE A1490
ASN A1459
ALA A1486
THR A1482
 None
 1.18A 3t3sB-1b89A:
0.0		 3t3sB-1b89A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		3 / 3 LYS A1415
PRO A1416
LEU A1417
 None
 0.85A 3tpxE-1b89A:
0.0		 3tpxE-1b89A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		3 / 3 SER A1229
ALA A1240
VAL A1241
 None
 0.68A 4o2bC-1b89A:
undetectable		 4o2bC-1b89A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		4 / 5 TYR A1324
LYS A1328
PRO A1329
GLU A1297
 None
 1.26A 4w5tA-1b89A:
0.0		 4w5tA-1b89A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		4 / 7 LEU A1364
LEU A1349
ALA A1351
ALA A1352
 None
 0.79A 6a7jA-1b89A:
undetectable		 6a7jA-1b89A:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1b89 PROTEIN (CLATHRIN
HEAVY CHAIN)
(Bos
taurus) 		4 / 6 ILE A1287
LEU A1283
MET A1302
THR A1301
 None
 1.01A 6nmfN-1b89A:
undetectable
6nmfW-1b89A:
0.0		 6nmfN-1b89A:
19.78
6nmfW-1b89A:
8.04