SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 ARG A 214
GLU A 233
TYR A 339
GLY A 365
GLY A 405
 ATP  A 500 (-2.7A)
None
None
None
None
 1.04A 1httB-1b8aA:
14.5		 1httB-1b8aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 ARG A 214
GLU A 233
TYR A 339
GLY A 365
GLY A 405
 ATP  A 500 (-2.7A)
None
None
None
None
 1.11A 1httD-1b8aA:
13.4		 1httD-1b8aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 6 PHE A 271
ARG A 358
TYR A 357
ILE A 414
 None
 1.19A 1oniH-1b8aA:
0.0
1oniI-1b8aA:
0.0		 1oniH-1b8aA:
14.55
1oniI-1b8aA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 SER A 363
PHE A 327
LEU A 325
ALA A 146
ALA A 254
 None
 1.23A 1q23A-1b8aA:
0.9
1q23B-1b8aA:
0.9		 1q23A-1b8aA:
18.37
1q23B-1b8aA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 7 PHE A 389
GLU A 196
TYR A 392
LEU A 193
 None
 1.08A 1rmtB-1b8aA:
undetectable		 1rmtB-1b8aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 GLY A 365
GLY A 366
GLY A 404
ASP A 354
SER A 364
 None
None
None
MN  A 601 ( 3.8A)
MN  A 601 ( 2.3A)
 1.18A 1wg8A-1b8aA:
undetectable		 1wg8A-1b8aA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 8 LEU A 375
PHE A 338
LEU A 175
SER A 388
 None
 1.03A 1wrlC-1b8aA:
undetectable
1wrlD-1b8aA:
undetectable		 1wrlC-1b8aA:
13.33
1wrlD-1b8aA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 9 PHE A 389
GLU A 196
TYR A 392
LEU A 193
GLY A 171
 None
 1.48A 2b82B-1b8aA:
0.0		 2b82B-1b8aA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 6 LEU A 418
MET A 417
LEU A 273
GLU A 265
 None
 1.28A 2kuhA-1b8aA:
0.0		 2kuhA-1b8aA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 9 ALA A 227
GLY A 409
ASP A 231
LEU A 408
ILE A 209
 ATP  A 500 ( 3.7A)
ATP  A 500 (-3.3A)
None
None
None
 1.32A 3wdmA-1b8aA:
undetectable		 3wdmA-1b8aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		3 / 3 PRO A 324
LEU A 325
GLN A 416
 None
 0.50A 4pevB-1b8aA:
undetectable		 4pevB-1b8aA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 5 ASP A  70
VAL A  71
TRP A  24
GLU A  69
 None
 1.18A 4qzuA-1b8aA:
0.0
4qzuD-1b8aA:
0.0		 4qzuA-1b8aA:
14.42
4qzuD-1b8aA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 ARG A 214
GLU A 233
TYR A 339
GLY A 365
GLY A 405
 ATP  A 500 (-2.7A)
None
None
None
None
 1.05A 5e3iA-1b8aA:
14.7		 5e3iA-1b8aA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 11 ARG A 214
GLU A 233
TYR A 339
GLY A 365
GLY A 405
 ATP  A 500 (-2.7A)
None
None
None
None
 1.08A 5e3iB-1b8aA:
14.5		 5e3iB-1b8aA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 7 GLY A 293
GLY A 296
GLU A 298
ASP A 294
 None
 0.68A 5ergB-1b8aA:
undetectable		 5ergB-1b8aA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 ILE A 305
GLY A 309
ALA A 288
GLU A 356
VAL A 283
 None
 1.14A 5hw4C-1b8aA:
undetectable		 5hw4C-1b8aA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 6 GLU A 233
GLY A 404
ARG A 368
PHE A 353
 None
 1.18A 5jcnB-1b8aA:
0.0		 5jcnB-1b8aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		3 / 3 LYS A 415
LEU A 266
ILE A 255
 None
 0.75A 5kc4A-1b8aA:
0.0		 5kc4A-1b8aA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		5 / 12 ALA A  73
VAL A  96
GLU A  75
GLY A  76
TYR A   2
 None
 0.97A 5n5dA-1b8aA:
undetectable		 5n5dA-1b8aA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		7 / 10 ARG A 214
GLU A 216
HIS A 223
GLU A 361
GLY A 409
ARG A 412
ILE A 423
 ATP  A 500 (-2.7A)
ATP  A 500 (-3.6A)
ATP  A 500 (-3.7A)
MN  A 601 (-2.6A)
ATP  A 500 (-3.3A)
ATP  A 500 (-2.5A)
None
 0.73A 6bniA-1b8aA:
30.0		 6bniA-1b8aA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		7 / 10 ARG A 214
GLU A 216
HIS A 223
GLU A 361
GLY A 409
ARG A 412
ILE A 423
 ATP  A 500 (-2.7A)
ATP  A 500 (-3.6A)
ATP  A 500 (-3.7A)
MN  A 601 (-2.6A)
ATP  A 500 (-3.3A)
ATP  A 500 (-2.5A)
None
 0.74A 6bniB-1b8aA:
30.1		 6bniB-1b8aA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		3 / 3 ARG A 412
LYS A 415
ARG A 130
 ATP  A 500 (-2.5A)
None
None
 1.33A 6c06D-1b8aA:
0.0		 6c06D-1b8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		3 / 3 GLY A  32
ASP A  30
ILE A  63
 None
 0.53A 6dgxB-1b8aA:
0.1		 6dgxB-1b8aA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)
(Thermococcus
kodakarensis) 		4 / 7 VAL A 143
ILE A 209
MET A 234
GLY A 404
 None
 0.78A 6hd6B-1b8aA:
undetectable		 6hd6B-1b8aA:
11.72