SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 7 VAL A 388
LEU A 380
LEU A 345
LEU A 425
 None
 0.74A 1cqpA-1b8gA:
2.2
1cqpB-1b8gA:
2.0		 1cqpA-1b8gA:
19.63
1cqpB-1b8gA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		5 / 9 LEU A 227
LEU A 178
GLU A 212
ILE A 163
VAL A 192
 None
 1.42A 1gx8A-1b8gA:
0.0		 1gx8A-1b8gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		5 / 11 LEU A 139
VAL A 192
ILE A 225
LEU A 215
LEU A 216
 None
 1.35A 1mrqA-1b8gA:
undetectable		 1mrqA-1b8gA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 6 LEU A 213
GLU A 248
LEU A 216
VAL A 267
 None
 1.12A 1sn5A-1b8gA:
0.0		 1sn5A-1b8gA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 ALA A  67
GLU A  64
SER A 314
LEU A 313
 None
 0.88A 2bxgA-1b8gA:
undetectable		 2bxgA-1b8gA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 ILE A 392
LEU A 345
VAL A 342
LEU A 341
 None
 0.89A 2w98B-1b8gA:
3.4		 2w98B-1b8gA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 ASP A 222
PHE A 219
LEU A 215
 None
 0.59A 2zi9A-1b8gA:
1.1		 2zi9A-1b8gA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 GLY A 404
MET A  43
CYH A 409
PHE A 410
 None
 1.05A 3ko0D-1b8gA:
undetectable
3ko0E-1b8gA:
0.0		 3ko0D-1b8gA:
13.21
3ko0E-1b8gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 GLY A 404
MET A  43
CYH A 409
PHE A 410
 None
 1.11A 3ko0B-1b8gA:
0.0
3ko0J-1b8gA:
0.0		 3ko0B-1b8gA:
13.21
3ko0J-1b8gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 7 GLY A 404
MET A  43
CYH A 409
PHE A 410
 None
 1.07A 3ko0L-1b8gA:
undetectable
3ko0N-1b8gA:
undetectable		 3ko0L-1b8gA:
13.21
3ko0N-1b8gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 7 GLY A 404
MET A  43
CYH A 409
PHE A 410
 None
 1.02A 3ko0K-1b8gA:
0.0
3ko0S-1b8gA:
0.0		 3ko0K-1b8gA:
13.21
3ko0S-1b8gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 7 GLY A 404
MET A  43
CYH A 409
PHE A 410
 None
 1.10A 3ko0R-1b8gA:
0.0
3ko0T-1b8gA:
undetectable		 3ko0R-1b8gA:
13.21
3ko0T-1b8gA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 LEU A 114
VAL A 267
TYR A 269
LEU A 116
 None
 0.99A 3v81A-1b8gA:
0.2		 3v81A-1b8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 5 HIS A 389
GLY A  39
TYR A 386
GLU A  25
 None
 1.36A 4ae1B-1b8gA:
0.0		 4ae1B-1b8gA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 7 LEU A 317
VAL A 282
TYR A 269
LEU A 275
 None
 1.15A 4b3qA-1b8gA:
0.0		 4b3qA-1b8gA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 PHE A 129
VAL A 268
ILE A 228
 None
 0.49A 4emaA-1b8gA:
0.0		 4emaA-1b8gA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 5 THR A 236
PHE A  98
ASN A 330
TYR A 326
 None
 1.22A 4mf6A-1b8gA:
0.0		 4mf6A-1b8gA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 LEU A 215
LEU A 250
ASN A 199
 None
 0.76A 4otwA-1b8gA:
0.0		 4otwA-1b8gA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 LEU A 114
VAL A 267
TYR A 269
LEU A 116
 None
 0.92A 4puoC-1b8gA:
undetectable		 4puoC-1b8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 GLU A 184
THR A 142
HIS A 164
 None
 0.79A 4ydqB-1b8gA:
undetectable		 4ydqB-1b8gA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 ASP A  53
ARG A 416
ARG A 337
 None
 0.91A 5eajB-1b8gA:
1.6		 5eajB-1b8gA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		5 / 12 ALA A  46
PHE A 360
GLY A 358
GLY A 205
LEU A 196
 None
 1.17A 5ul4A-1b8gA:
2.6		 5ul4A-1b8gA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 ARG A 333
ALA A 328
PHE A  98
THR A 236
 None
 0.85A 5v0vA-1b8gA:
0.0		 5v0vA-1b8gA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 HIS A 331
PHE A 243
PRO A 200
TYR A 269
 None
 1.33A 5v4vA-1b8gA:
2.9		 5v4vA-1b8gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 8 HIS A 331
PHE A 243
PRO A 200
TYR A 269
 None
 1.33A 5v4vB-1b8gA:
2.5		 5v4vB-1b8gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		4 / 6 ASN A 124
PHE A 148
TYR A 233
SER A 270
 PLP  A 500 ( 4.2A)
None
PLP  A 500 ( 4.4A)
PLP  A 500 ( 2.6A)
 1.46A 6a7pB-1b8gA:
0.0		 6a7pB-1b8gA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		3 / 3 PRO A 394
SER A 396
SER A 397
 None
 0.69A 6bpyA-1b8gA:
0.0		 6bpyA-1b8gA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)
(Malus
domestica) 		5 / 10 ARG A 407
ALA A  46
LEU A 359
GLY A 358
LEU A  59
 None
 1.34A 6hqbA-1b8gA:
undetectable
6hqbJ-1b8gA:
0.0		 6hqbA-1b8gA:
12.41
6hqbJ-1b8gA:
7.40