SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 7 THR A 141
ASN A 142
GLY A 145
ASP A 144
 None
 1.01A 1bu5A-1b8hA:
undetectable		 1bu5A-1b8hA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.93A 1drbB-1b8hA:
undetectable		 1drbB-1b8hA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 11 LEU A  64
GLU A  72
ILE A  73
LEU A  57
LEU A  54
 None
 1.34A 1mrqA-1b8hA:
undetectable		 1mrqA-1b8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.98A 1ra2A-1b8hA:
undetectable		 1ra2A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.97A 1ra8A-1b8hA:
undetectable		 1ra8A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.93A 1rb2A-1b8hA:
undetectable		 1rb2A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.96A 1rb2B-1b8hA:
undetectable		 1rb2B-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.95A 1rd7A-1b8hA:
undetectable		 1rd7A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ALA A  42
THR A  31
ILE A  21
LEU A  57
TYR A 216
 None
 1.04A 1rg7A-1b8hA:
undetectable		 1rg7A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 1.00A 1rx2A-1b8hA:
undetectable		 1rx2A-1b8hA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		6 / 12 ILE A  81
LEU A  57
PHE A  60
ILE A   8
LEU A  64
ILE A  73
 None
 1.37A 2d0kA-1b8hA:
undetectable		 2d0kA-1b8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 1.00A 2d0kB-1b8hA:
undetectable		 2d0kB-1b8hA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 5 ASP A  46
ILE A  73
VAL A  52
THR A  31
 None
 1.13A 3eigA-1b8hA:
undetectable		 3eigA-1b8hA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.90A 4ej1A-1b8hA:
undetectable		 4ej1A-1b8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.89A 4fhbA-1b8hA:
undetectable		 4fhbA-1b8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 11 ILE A  81
ALA A  53
LEU A  57
PHE A  60
LEU A   3
 None
 1.38A 4i1nA-1b8hA:
undetectable		 4i1nA-1b8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 12 ILE A  81
LEU A  57
PHE A  60
LEU A  64
ILE A  73
 None
 0.98A 4p3rA-1b8hA:
undetectable		 4p3rA-1b8hA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		5 / 8 ILE A 149
LEU A 169
ILE A 140
ILE A 182
SER A 215
 None
 1.25A 5numA-1b8hA:
0.0		 5numA-1b8hA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 7 ALA A  40
THR A  31
GLN A 213
VAL A 214
 None
 0.93A 6cduA-1b8hA:
undetectable
6cduE-1b8hA:
undetectable		 6cduA-1b8hA:
21.39
6cduE-1b8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 6 GLN A 213
VAL A 214
ALA A  40
THR A  31
 None
 0.84A 6cduB-1b8hA:
undetectable
6cduC-1b8hA:
undetectable		 6cduB-1b8hA:
21.39
6cduC-1b8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 8 GLN A 213
VAL A 214
ALA A  40
THR A  31
 None
 0.87A 6cduD-1b8hA:
0.0
6cduE-1b8hA:
undetectable		 6cduD-1b8hA:
21.39
6cduE-1b8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 7 ALA A  40
THR A  31
GLN A 213
VAL A 214
 None
 0.90A 6cduF-1b8hA:
undetectable
6cduJ-1b8hA:
0.0		 6cduF-1b8hA:
21.39
6cduJ-1b8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT
(Escherichia
virus
RB69) 		4 / 7 GLN A 213
VAL A 214
ALA A  40
THR A  31
 None
 0.93A 6cduH-1b8hA:
undetectable
6cduI-1b8hA:
undetectable		 6cduH-1b8hA:
21.39
6cduI-1b8hA:
21.39