SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		5 / 12 THR A 122
ASN A 123
HIS A 124
ILE A 145
LEU A 140
 None
 1.03A 1r30B-1b8iA:
undetectable		 1r30B-1b8iA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		4 / 6 LEU A 138
ARG A 129
THR A 127
LEU A 126
 None
 1.05A 3abmA-1b8iA:
undetectable
3abmJ-1b8iA:
undetectable		 3abmA-1b8iA:
9.53
3abmJ-1b8iA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		4 / 5 LYS A 118
LEU A 116
GLU A 115
LEU A 138
 None
 1.38A 4k4yA-1b8iA:
undetectable		 4k4yA-1b8iA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		4 / 4 LYS A 118
LEU A 116
GLU A 115
LEU A 138
 None
 1.41A 4k4yE-1b8iA:
undetectable		 4k4yE-1b8iA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		3 / 3 PRO A  90
MET A  92
TYR A  89
 None
 1.10A 4qa0B-1b8iA:
undetectable		 4qa0B-1b8iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		3 / 3 PRO A  90
MET A  92
TYR A  89
 None
 1.11A 4qa0A-1b8iA:
undetectable		 4qa0A-1b8iA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		3 / 3 PRO A  90
MET A  92
TYR A  89
 None
 0.95A 4qa2B-1b8iA:
undetectable		 4qa2B-1b8iA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		3 / 3 TRP A 148
ARG A 152
LEU A 126
 None
 0.76A 5dbyA-1b8iA:
undetectable		 5dbyA-1b8iA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1b8i PROTEIN
(ULTRABITHORAX
HOMEOTIC PROTEIN IV)
(Drosophila
melanogaster) 		4 / 6 LEU A 138
ARG A 129
THR A 127
LEU A 126
 None
 0.89A 5x1fA-1b8iA:
undetectable
5x1fJ-1b8iA:
undetectable		 5x1fA-1b8iA:
9.53
5x1fJ-1b8iA:
18.18