SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 11 LEU A 167
ALA A 201
GLY A 205
VAL A 178
ILE A 181
 None
 1.04A 1sduA-1b8uA:
0.0		 1sduA-1b8uA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 8 ALA A  13
LEU A  88
ILE A  25
VAL A  86
ILE A 127
 None
 1.37A 2uxpA-1b8uA:
undetectable		 2uxpA-1b8uA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 11 GLY A  12
GLY A  15
GLU A  43
ILE A  44
ILE A 111
 NAD  A 334 (-3.2A)
NAD  A 334 (-3.3A)
NAD  A 334 (-2.9A)
NAD  A 334 (-4.0A)
NAD  A 334 ( 4.0A)
 0.63A 3grvA-1b8uA:
4.7		 3grvA-1b8uA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		6 / 12 GLY A 133
ALA A  92
ILE A  44
GLY A  12
PRO A  77
ILE A 111
 NAD  A 334 (-3.6A)
NAD  A 334 (-3.5A)
NAD  A 334 (-4.0A)
NAD  A 334 (-3.2A)
None
NAD  A 334 ( 4.0A)
 1.48A 3k4vA-1b8uA:
undetectable		 3k4vA-1b8uA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		4 / 8 ASN A 154
THR A 156
LEU A 130
ALA A  87
 None
 1.01A 3kp6A-1b8uA:
0.0		 3kp6A-1b8uA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		4 / 6 TYR A 275
GLN A 307
ILE A 302
SER A 271
 None
 1.26A 3pmzD-1b8uA:
0.0		 3pmzD-1b8uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		3 / 3 SER A 168
ASP A 251
ASP A  29
 None
 0.86A 3uj7A-1b8uA:
5.8		 3uj7A-1b8uA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 11 GLY A 268
GLY A 284
GLY A 188
ALA A 157
LEU A 159
 None
 1.16A 4l8fB-1b8uA:
2.5		 4l8fB-1b8uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 11 GLY A 268
GLY A 284
GLY A 188
ALA A 157
LEU A 159
 None
 1.16A 4l8fD-1b8uA:
undetectable		 4l8fD-1b8uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		4 / 6 VAL A   8
LEU A  39
LEU A  21
PHE A 112
 None
 1.08A 4o1zA-1b8uA:
0.0		 4o1zA-1b8uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 12 ASP A  29
LEU A  88
ARG A  24
LEU A  22
ILE A  25
 None
 1.09A 4x1fA-1b8uA:
0.0		 4x1fA-1b8uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 12 ASP A  29
LEU A  88
ARG A  24
LEU A  22
ILE A  25
 None
 1.07A 4x1gA-1b8uA:
undetectable		 4x1gA-1b8uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		4 / 8 THR A 156
LEU A 130
ILE A 253
LEU A  88
 None
 0.74A 5g48A-1b8uA:
undetectable		 5g48A-1b8uA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		3 / 3 TYR A 275
SER A 301
TRP A 187
 None
 1.07A 5n8jD-1b8uA:
undetectable		 5n8jD-1b8uA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1b8u PROTEIN (MALATE
DEHYDROGENASE)
(Aquaspirillum
arcticum) 		5 / 12 GLY A 276
ASN A 189
GLU A 316
LEU A 318
GLU A 319
 None
 0.95A 5nwuA-1b8uA:
0.0		 5nwuA-1b8uA:
10.55