SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 7 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.59A 11gsB-1b8xA:
23.9		 11gsB-1b8xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 7 TYR A 110
GLY A 204
TYR A   6
GLY A  11
 None
 0.82A 11gsB-1b8xA:
23.9		 11gsB-1b8xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 12 ILE A   3
TYR A  27
LEU A  20
TYR A  73
ILE A  70
 None
 1.21A 1fmlB-1b8xA:
0.0		 1fmlB-1b8xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 11 TYR A 163
PRO A  15
LEU A  18
ARG A  17
ALA A 199
 None
 1.09A 1hk3A-1b8xA:
1.6		 1hk3A-1b8xA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 5 TYR A 103
ALA A 109
ALA A 157
MET A 128
 None
 1.15A 3d91A-1b8xA:
0.0		 3d91A-1b8xA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 8 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.65A 3n9jB-1b8xA:
23.6		 3n9jB-1b8xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 9 LEU A 125
ALA A 157
ASP A 156
LEU A  99
ILE A 101
 None
 1.37A 3wsjA-1b8xA:
undetectable		 3wsjA-1b8xA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 12 PHE A 121
GLN A 203
ALA A 109
ASP A 165
MET A 164
 None
 1.28A 4j7xA-1b8xA:
undetectable		 4j7xA-1b8xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 8 ASP A 100
TYR A 103
GLY A  96
ALA A 157
 None
 0.80A 4m48A-1b8xA:
0.0		 4m48A-1b8xA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 9 LEU A   4
GLY A   5
ILE A  71
SER A  67
THR A  16
 None
 1.08A 4x3mA-1b8xA:
undetectable		 4x3mA-1b8xA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 7 VAL A 105
SER A 106
ALA A 109
GLY A 210
 None
 0.84A 5fpdA-1b8xA:
undetectable		 5fpdA-1b8xA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 7 VAL A 105
SER A 106
ALA A 109
GLY A 204
 None
 0.91A 5fpdB-1b8xA:
0.0		 5fpdB-1b8xA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 7 VAL A 105
SER A 106
ALA A 109
GLY A 210
 None
 0.85A 5fpdB-1b8xA:
0.0		 5fpdB-1b8xA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 8 LEU A  20
PRO A   2
ILE A  74
LEU A  19
 None
 0.94A 5g48A-1b8xA:
undetectable		 5g48A-1b8xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		5 / 12 LEU A 169
ALA A 157
LEU A 142
LEU A 129
LEU A 175
 None
 1.07A 6f6iA-1b8xA:
undetectable
6f6iB-1b8xA:
undetectable		 6f6iA-1b8xA:
17.95
6f6iB-1b8xA:
13.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 5 GLY A  11
LEU A  12
SER A 106
TYR A 110
 None
 0.81A 6ji6A-1b8xA:
33.5		 6ji6A-1b8xA:
82.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1b8x PROTEIN (AML-1B)
(Escherichia
coli) 		4 / 5 GLY A  11
LEU A  12
TYR A 110
GLN A 203
 None
 0.84A 6ji6A-1b8xA:
33.5		 6ji6A-1b8xA:
82.35