SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b9b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 4 THR A  46
LEU A  48
VAL A  51
LEU A  55
 None
 0.86A 1fbmD-1b9bA:
undetectable		 1fbmD-1b9bA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 7 ASP A 230
LEU A 210
ILE A 207
ARG A 192
 None
 0.97A 1n13I-1b9bA:
undetectable
1n13L-1b9bA:
0.0		 1n13I-1b9bA:
13.17
1n13L-1b9bA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 7 PHE A 190
LEU A 194
LEU A 195
GLU A 130
 None
 0.95A 2jn3A-1b9bA:
undetectable		 2jn3A-1b9bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 7 ILE A 207
ARG A 192
ASP A 230
LEU A 210
 None
 0.97A 2qqcB-1b9bA:
0.0
2qqcC-1b9bA:
undetectable		 2qqcB-1b9bA:
20.78
2qqcC-1b9bA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 7 ASP A 230
LEU A 210
ILE A 207
ARG A 192
 None
 0.98A 2qqcA-1b9bA:
0.0
2qqcF-1b9bA:
0.0		 2qqcA-1b9bA:
12.55
2qqcF-1b9bA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 7 ASP A 230
LEU A 210
ILE A 207
ARG A 192
 None
 0.98A 2qqcI-1b9bA:
0.0
2qqcL-1b9bA:
undetectable		 2qqcI-1b9bA:
12.55
2qqcL-1b9bA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 9 LEU A  31
VAL A  40
GLY A 231
ILE A 224
ILE A  39
 None
 0.95A 3el0B-1b9bA:
undetectable		 3el0B-1b9bA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 9 VAL A  89
LEU A 233
ILE A  93
ALA A  64
ALA A   8
 None
 1.12A 3mdvA-1b9bA:
undetectable		 3mdvA-1b9bA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 12 ALA A 237
GLY A 235
TRP A  11
SER A 214
ASP A 218
 None
SO4  A 301 (-3.3A)
None
SO4  A 301 (-3.7A)
None
 1.17A 3ou7D-1b9bA:
undetectable		 3ou7D-1b9bA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		3 / 3 ARG A 208
ARG A   3
ILE A   6
 None
 0.92A 4b7qA-1b9bA:
undetectable		 4b7qA-1b9bA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 9 THR A 203
LEU A 195
ALA A 160
LEU A 126
PHE A 152
 None
 1.38A 4ltwA-1b9bA:
undetectable		 4ltwA-1b9bA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 5 LYS A 161
ARG A 162
LEU A 155
ASP A 156
 None
 1.14A 4xdtA-1b9bA:
0.0		 4xdtA-1b9bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 6 GLU A 130
ARG A 135
LEU A 132
ARG A 101
 None
 1.24A 5l6eA-1b9bA:
undetectable
5l6eB-1b9bA:
undetectable		 5l6eA-1b9bA:
23.46
5l6eB-1b9bA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 12 GLU A 168
HIS A  96
THR A 131
SER A  97
GLY A 129
 None
 1.37A 5xioA-1b9bA:
undetectable		 5xioA-1b9bA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		4 / 8 LEU A 195
LEU A 194
LEU A 155
GLY A 154
 None
 0.94A 6ce2A-1b9bA:
0.0		 6ce2A-1b9bA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)
(Thermotoga
maritima) 		5 / 12 GLU A 168
HIS A  96
THR A 131
SER A  97
GLY A 129
 None
 1.28A 6mn8A-1b9bA:
undetectable		 6mn8A-1b9bA:
19.34