SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1b9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 8 ASP A 159
ALA A 161
GLY A 195
GLY A 196
ALA A  94
 PLP  A 389 (-2.8A)
PLP  A 389 (-3.5A)
None
None
None
 1.00A 1sguA-1b9hA:
0.0		 1sguA-1b9hA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 10 THR A 181
GLY A  62
GLY A 196
ILE A 179
ALA A  69
 None
PLP  A 389 (-3.5A)
None
None
None
 1.06A 1x7pA-1b9hA:
undetectable
1x7pB-1b9hA:
undetectable		 1x7pA-1b9hA:
24.76
1x7pB-1b9hA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		3 / 3 ASP A 151
VAL A 119
PRO A 132
 None
 0.77A 2avvA-1b9hA:
undetectable		 2avvA-1b9hA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 MET A 131
ALA A  85
ALA A  69
ALA A  65
MET A 135
 None
 1.22A 2x2nA-1b9hA:
undetectable		 2x2nA-1b9hA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 MET A 131
ALA A  85
ALA A  69
ALA A  65
MET A 135
 None
 1.21A 2x2nB-1b9hA:
undetectable		 2x2nB-1b9hA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 GLY A 137
ASP A 282
TRP A 168
ARG A 284
 None
 1.05A 3arrA-1b9hA:
undetectable		 3arrA-1b9hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 GLY A 137
ASP A 282
TRP A 168
ARG A 284
 None
 1.08A 3aruA-1b9hA:
undetectable		 3aruA-1b9hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 9 ALA A 293
LEU A 270
ILE A 297
LEU A 308
TYR A 112
 None
 1.28A 3fl9D-1b9hA:
undetectable		 3fl9D-1b9hA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		3 / 3 ARG A  25
ASP A  16
GLN A 255
 None
 0.92A 3lcvB-1b9hA:
undetectable		 3lcvB-1b9hA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 362
VAL A 276
GLY A 271
SER A 267
LEU A 266
 None
 1.08A 3pghD-1b9hA:
0.0		 3pghD-1b9hA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 8 GLU A 314
ILE A 297
VAL A 276
PHE A 295
 None
 1.01A 4dx7B-1b9hA:
undetectable		 4dx7B-1b9hA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 THR A 102
ALA A 100
THR A  79
VAL A  81
 None
 0.80A 4ik7A-1b9hA:
0.0		 4ik7A-1b9hA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 8 THR A 102
ALA A 100
THR A  79
VAL A  81
 None
 0.77A 4ik7B-1b9hA:
undetectable		 4ik7B-1b9hA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 ALA A 180
THR A 181
ALA A 197
MET A 139
 None
 0.99A 4qw0K-1b9hA:
undetectable		 4qw0K-1b9hA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 ALA A 180
THR A 181
ALA A 197
MET A 139
 None
 0.98A 4qw0Y-1b9hA:
undetectable		 4qw0Y-1b9hA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 8 ALA A  95
ILE A 345
THR A  87
VAL A 133
 None
None
PLP  A 389 (-4.6A)
None
 0.80A 4r20A-1b9hA:
0.0		 4r20A-1b9hA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		3 / 3 MET A 142
GLN A 279
TYR A 112
 None
 0.95A 4udcA-1b9hA:
0.0		 4udcA-1b9hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 7 ALA A  58
ARG A 172
GLY A 174
GLU A 175
 None
 0.87A 5bs8A-1b9hA:
1.0
5bs8C-1b9hA:
1.1
5bs8D-1b9hA:
0.2		 5bs8A-1b9hA:
22.31
5bs8C-1b9hA:
22.31
5bs8D-1b9hA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		4 / 5 ALA A  58
GLU A  44
ASN A  41
GLU A 239
 None
 1.35A 5dwkC-1b9hA:
undetectable		 5dwkC-1b9hA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 ILE A  89
VAL A  83
ALA A 140
GLY A 137
TYR A 291
 None
 1.28A 5igpA-1b9hA:
0.0		 5igpA-1b9hA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 362
VAL A 276
GLY A 271
SER A 267
LEU A 266
 None
 1.05A 5jvzA-1b9hA:
0.0		 5jvzA-1b9hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 LEU A 362
VAL A 276
GLY A 271
SER A 267
LEU A 266
 None
 1.06A 5jw1A-1b9hA:
0.0		 5jw1A-1b9hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 12 THR A 181
GLY A  62
GLY A 196
ILE A 179
ALA A  69
 None
PLP  A 389 (-3.5A)
None
None
None
 1.03A 5l0zA-1b9hA:
undetectable		 5l0zA-1b9hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		5 / 10 THR A 181
GLY A  62
GLY A 196
ILE A 179
ALA A  69
 None
PLP  A 389 (-3.5A)
None
None
None
 0.94A 5l0zB-1b9hA:
undetectable		 5l0zB-1b9hA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)
(Amycolatopsis
mediterranei) 		3 / 3 ILE A 355
VAL A 107
PRO A  84
 None
 0.71A 5uunA-1b9hA:
0.0		 5uunA-1b9hA:
23.17