SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bbj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		3 / 3 TRP L  35
ALA L  50
VAL L  48
 None
 0.92A 1c4dC-1bbjL:
undetectable
1c4dD-1bbjL:
undetectable		 1c4dC-1bbjL:
7.10
1c4dD-1bbjL:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU L 135
ALA H 138
SER H 133
THR H 136
 None
 0.98A 1ictB-1bbjL:
3.9		 1ictB-1bbjL:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		4 / 5 SER L 162
LEU H 125
LEU L 135
LEU H 142
 None
 1.13A 1yajD-1bbjL:
undetectable		 1yajD-1bbjL:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.83A 2aojA-1bbjL:
undetectable		 2aojA-1bbjL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.78A 2aojB-1bbjL:
0.0		 2aojB-1bbjL:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 5 ILE H  34
HIS H  35
TYR H  27
GLY H 102
 None
 1.29A 3b9mA-1bbjH:
undetectable		 3b9mA-1bbjH:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus) 		6 / 12 ILE H  48
GLY H  49
ALA H  33
PHE H  64
ILE H  58
PRO L  95
 None
 1.39A 3jb1A-1bbjH:
0.0		 3jb1A-1bbjH:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 6 ILE L   2
GLU L  27
ALA L  25
ASN L  28
 None
 1.10A 3pgyA-1bbjL:
undetectable
3pgyB-1bbjL:
undetectable		 3pgyA-1bbjL:
19.76
3pgyB-1bbjL:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		5 / 12 GLY L 128
LEU L 181
SER L 131
ASP L 185
ALA L 184
 None
 0.96A 4krhA-1bbjL:
undetectable		 4krhA-1bbjL:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)
(Homo
sapiens;
Mus
musculus) 		3 / 3 PRO H 186
SER H 188
SER H 189
 None
 0.68A 6bpyA-1bbjH:
undetectable		 6bpyA-1bbjH:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 8 GLY L  84
LEU L 104
VAL L  15
LEU L  78
 None
 0.73A 6czmD-1bbjL:
2.1
6czmF-1bbjL:
0.0		 6czmD-1bbjL:
23.12
6czmF-1bbjL:
23.12