SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bbu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
 0.73A 1d4sB-1bbuA:
0.0		 1d4sB-1bbuA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
 0.67A 1d4yB-1bbuA:
0.0		 1d4yB-1bbuA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_1
(DIHYDROFOLATE
REDUCTASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 4 GLU A 256
ASN A 424
ARG A 262
THR A 207
 None
LYS  A 505 (-4.0A)
LYS  A 505 (-4.0A)
None
 1.37A 1drfA-1bbuA:
0.2		 1drfA-1bbuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 7 SER A 488
THR A 486
ASN A 487
TYR A 312
 None
 1.05A 1dssG-1bbuA:
undetectable		 1dssG-1bbuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 SER A 488
THR A 486
ASN A 487
TYR A 312
 None
 1.04A 1dssR-1bbuA:
undetectable		 1dssR-1bbuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 262
ASP A 450
ASP A 447
 LYS  A 505 (-4.0A)
None
None
 0.86A 2ejtA-1bbuA:
undetectable		 2ejtA-1bbuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		3 / 3 PHE A 415
PHE A 297
PHE A 319
 None
 0.74A 2od9A-1bbuA:
undetectable		 2od9A-1bbuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		3 / 3 PHE A 415
PHE A 297
PHE A 319
 None
 0.74A 2qqgA-1bbuA:
undetectable		 2qqgA-1bbuA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 7 GLY A 418
GLY A 477
PHE A 297
PHE A 319
 None
 0.96A 2qwxA-1bbuA:
undetectable
2qwxB-1bbuA:
undetectable		 2qwxA-1bbuA:
18.05
2qwxB-1bbuA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 TYR A 312
THR A 293
LEU A 300
THR A 390
 None
 0.97A 2v0zO-1bbuA:
undetectable		 2v0zO-1bbuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 GLY A 425
ASN A 424
PHE A 416
ARG A 412
 LYS  A 505 ( 4.1A)
LYS  A 505 (-4.0A)
None
None
 1.32A 3ccfA-1bbuA:
undetectable		 3ccfA-1bbuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 SER A 488
THR A 486
ASN A 487
TYR A 312
 None
 0.94A 3dmtC-1bbuA:
undetectable		 3dmtC-1bbuA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 10 CYH A 139
ILE A 137
VAL A  69
GLY A 122
LEU A 103
 None
 1.24A 3em0A-1bbuA:
0.0		 3em0A-1bbuA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 6 LEU A  87
LEU A  48
ARG A  41
LEU A  96
 None
 1.02A 3f33A-1bbuA:
undetectable		 3f33A-1bbuA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 7 ARG A  76
SER A  83
VAL A  85
VAL A  98
 None
 0.85A 3o14A-1bbuA:
0.0		 3o14A-1bbuA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 7 ARG A 186
GLY A 423
ILE A 422
THR A 275
 None
 0.82A 3spkB-1bbuA:
0.0		 3spkB-1bbuA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 7 LEU A 326
ALA A 379
GLY A 419
ILE A 384
 None
 0.74A 3spkB-1bbuA:
0.0		 3spkB-1bbuA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ARG A 480
ILE A 491
GLU A 452
GLU A 380
GLU A 414
 None
 1.22A 4a97A-1bbuA:
0.0
4a97B-1bbuA:
0.0		 4a97A-1bbuA:
19.52
4a97B-1bbuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_G_ZPCG1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ARG A 480
ILE A 491
GLU A 452
GLU A 380
GLU A 414
 None
 1.27A 4a97F-1bbuA:
0.0
4a97G-1bbuA:
0.0		 4a97F-1bbuA:
19.52
4a97G-1bbuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 9 TYR A 280
PHE A 426
ILE A 476
MET A 276
 LYS  A 505 (-4.6A)
LYS  A 505 (-3.7A)
None
LYS  A 505 ( 4.9A)
 1.19A 4jvlA-1bbuA:
0.0		 4jvlA-1bbuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ARG A 262
PHE A 274
GLY A 423
ARG A 480
 LYS  A 505 (-4.0A)
None
None
None
 0.51A 4k87A-1bbuA:
10.7		 4k87A-1bbuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ASN A 424
ALA A 218
GLU A 428
GLU A 240
LEU A 241
 LYS  A 505 (-4.0A)
None
LYS  A 505 (-3.0A)
LYS  A 505 (-2.9A)
None
 1.29A 4zjoA-1bbuA:
0.0		 4zjoA-1bbuA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 6 HIS A 466
VAL A 248
LEU A 464
THR A 462
 None
 1.29A 5ogjA-1bbuA:
undetectable		 5ogjA-1bbuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 5 HIS A 466
VAL A 248
LEU A 464
THR A 462
 None
 1.30A 5ohhA-1bbuA:
undetectable		 5ohhA-1bbuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
 None
LYS  A 505 (-4.0A)
None
None
None
 0.76A 6bniA-1bbuA:
46.3		 6bniA-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		7 / 10 ASN A 260
ARG A 262
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LYS  A 505 (-4.0A)
None
None
None
None
None
 0.62A 6bniA-1bbuA:
46.3		 6bniA-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		7 / 10 ASN A 260
ARG A 262
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 None
LYS  A 505 (-4.0A)
None
None
None
None
None
 0.56A 6bniA-1bbuA:
46.3		 6bniA-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		5 / 10 ASN A 260
ARG A 262
PHE A 274
GLY A 477
ILE A 495
 None
LYS  A 505 (-4.0A)
None
None
None
 1.20A 6bniA-1bbuA:
46.3		 6bniA-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		6 / 10 ASN A 260
ARG A 262
GLU A 264
HIS A 270
PHE A 274
ILE A 491
 None
LYS  A 505 (-4.0A)
None
None
None
None
 0.75A 6bniB-1bbuA:
46.1		 6bniB-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		7 / 10 ASN A 260
ARG A 262
HIS A 270
PHE A 274
GLY A 477
ARG A 480
ILE A 491
 None
LYS  A 505 (-4.0A)
None
None
None
None
None
 0.60A 6bniB-1bbuA:
46.1		 6bniB-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		7 / 10 ASN A 260
ARG A 262
PHE A 274
GLU A 421
GLY A 477
ARG A 480
ILE A 491
 None
LYS  A 505 (-4.0A)
None
None
None
None
None
 0.53A 6bniB-1bbuA:
46.1		 6bniB-1bbuA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.04A 6c06C-1bbuA:
0.9		 6c06C-1bbuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A 361
GLU A 362
ILE A 370
 None
 0.49A 6f7lB-1bbuA:
undetectable		 6f7lB-1bbuA:
23.80