SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		5 / 10 ASP A  80
PHE A  51
LEU A  46
THR A  75
THR A  89
 None
 1.37A 1rmtA-1bd8A:
0.0		 1rmtA-1bd8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		3 / 3 HIS A 161
ILE A 111
LEU A 154
 None
 0.72A 2kceA-1bd8A:
undetectable		 2kceA-1bd8A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		5 / 12 VAL A  24
LEU A  12
LEU A  46
ILE A  56
ALA A  65
 None
 1.01A 4p65B-1bd8A:
undetectable
4p65D-1bd8A:
undetectable
4p65I-1bd8A:
undetectable
4p65J-1bd8A:
undetectable		 4p65B-1bd8A:
10.96
4p65D-1bd8A:
10.96
4p65I-1bd8A:
6.94
4p65J-1bd8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		5 / 12 LEU A  46
VAL A  24
LEU A  12
ILE A  56
ALA A  65
 None
 1.04A 4p65F-1bd8A:
undetectable
4p65H-1bd8A:
undetectable
4p65K-1bd8A:
undetectable
4p65L-1bd8A:
undetectable		 4p65F-1bd8A:
10.96
4p65H-1bd8A:
10.96
4p65K-1bd8A:
6.94
4p65L-1bd8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		4 / 7 VAL A 123
SER A 124
ALA A 127
GLY A 160
 None
 0.86A 5fpdB-1bd8A:
undetectable		 5fpdB-1bd8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 1bd8 P19INK4D CDK4/6
INHIBITOR
(Homo
sapiens) 		3 / 3 LEU A 126
SER A 124
PHE A 125
 None
 0.67A 6fgcA-1bd8A:
undetectable		 6fgcA-1bd8A:
18.14