SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1be4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		4 / 6 MET A  68
VAL A  65
LEU A  64
PHE A  60
 None
None
PCG  A 160 ( 4.6A)
PCG  A 160 (-3.4A)
 1.01A 1x8vA-1be4A:
undetectable		 1x8vA-1be4A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		4 / 8 MET A  68
LEU A  64
ARG A 105
GLY A 119
 None
PCG  A 160 ( 4.6A)
PCG  A 160 ( 4.6A)
None
 0.99A 2qd5A-1be4A:
undetectable		 2qd5A-1be4A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		3 / 4 SER A  99
GLY A 119
GLU A   5
 None
 0.63A 3raeA-1be4A:
0.0
3raeC-1be4A:
0.0		 3raeA-1be4A:
16.94
3raeC-1be4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		4 / 6 HIS A 118
GLU A 129
ASP A 121
SER A 125
 PCG  A 160 ( 3.7A)
None
None
None
 1.23A 4apjA-1be4A:
undetectable
4apjP-1be4A:
undetectable		 4apjA-1be4A:
14.77
4apjP-1be4A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		3 / 4 SER A  99
GLY A 119
GLU A   5
 None
 0.62A 4juoA-1be4A:
undetectable
4juoC-1be4A:
undetectable		 4juoA-1be4A:
16.94
4juoC-1be4A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		6 / 12 ILE A 104
ALA A  97
PHE A 108
ARG A  88
HIS A 118
ILE A 116
 None
None
None
PCG  A 160 ( 4.8A)
PCG  A 160 ( 3.7A)
None
 1.50A 4rvdA-1be4A:
undetectable		 4rvdA-1be4A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1be4 NUCLEOSIDE
DIPHOSPHATE
TRANSFERASE
(Bos
taurus) 		4 / 4 GLY A  71
PRO A  72
VAL A  73
ARG A  42
 None
 1.11A 5uunA-1be4A:
0.0
5uunB-1be4A:
0.0		 5uunA-1be4A:
20.15
5uunB-1be4A:
20.15