SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 5 LEU A 262
THR A 263
ARG A  46
VAL A  48
 None
 1.04A 1ekjF-1bf6A:
undetectable
1ekjG-1bf6A:
0.5		 1ekjF-1bf6A:
22.30
1ekjG-1bf6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 6 HIS A  12
HIS A  14
HIS A 158
HIS A 186
ASP A 243
 ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
ZN  A 293 (-3.3A)
ZN  A 293 (-3.3A)
ZN  A   1 (-2.7A)
 0.82A 1fweC-1bf6A:
12.8		 1fweC-1bf6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 243
HIS A 186
HIS A  12
 ZN  A   1 (-2.7A)
ZN  A 293 (-3.3A)
ZN  A   1 (-3.5A)
 0.65A 1oe1A-1bf6A:
undetectable		 1oe1A-1bf6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 243
HIS A 186
HIS A  12
 ZN  A   1 (-2.7A)
ZN  A 293 (-3.3A)
ZN  A   1 (-3.5A)
 0.65A 1oe3A-1bf6A:
undetectable		 1oe3A-1bf6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 ARG A 232
ILE A 196
LEU A 166
GLY A 165
 None
 0.68A 1rtsB-1bf6A:
0.0		 1rtsB-1bf6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 HIS A 186
ASN A 192
THR A 157
GLY A 185
 ZN  A 293 (-3.3A)
SO4  A 294 ( 4.9A)
None
None
 0.93A 2f6dA-1bf6A:
0.0		 2f6dA-1bf6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 GLU A 125
PHE A 291
ILE A 122
PHE A 290
 ZN  A 293 ( 2.5A)
None
None
None
 1.03A 2qmzA-1bf6A:
undetectable
2qmzB-1bf6A:
undetectable		 2qmzA-1bf6A:
18.92
2qmzB-1bf6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 11 HIS A 148
ALA A 147
VAL A 177
GLY A  82
ILE A 126
 None
 1.21A 2uxpB-1bf6A:
0.0		 2uxpB-1bf6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 243
HIS A 186
HIS A  12
 ZN  A   1 (-2.7A)
ZN  A 293 (-3.3A)
ZN  A   1 (-3.5A)
 0.67A 2xxgA-1bf6A:
undetectable		 2xxgA-1bf6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 243
HIS A 186
HIS A  12
 ZN  A   1 (-2.7A)
ZN  A 293 (-3.3A)
ZN  A   1 (-3.5A)
 0.68A 2xxgC-1bf6A:
undetectable		 2xxgC-1bf6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 141
GLU A 167
MET A 164
VAL A 184
 None
SO4  A 294 ( 4.5A)
SO4  A 294 (-3.6A)
None
 1.40A 3nlnA-1bf6A:
0.0
3nlnB-1bf6A:
0.0		 3nlnA-1bf6A:
23.43
3nlnB-1bf6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 108
THR A  55
ALA A 120
ALA A  79
 None
 1.13A 3ns1C-1bf6A:
0.1		 3ns1C-1bf6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 220
LYS A 221
ASP A 219
TYR A 217
 None
 1.48A 3pocB-1bf6A:
2.5		 3pocB-1bf6A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 9 LEU A  15
VAL A  77
LEU A  43
THR A  73
ILE A  75
 None
 1.18A 3tbgD-1bf6A:
0.0		 3tbgD-1bf6A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.02A 4a97E-1bf6A:
0.0		 4a97E-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 8 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.03A 4a97C-1bf6A:
0.0		 4a97C-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 8 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 0.98A 4a97D-1bf6A:
0.0		 4a97D-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 8 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.04A 4a97G-1bf6A:
undetectable		 4a97G-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 PHE A   3
VAL A  78
ARG A 153
ILE A 122
 None
 1.05A 4a97H-1bf6A:
undetectable		 4a97H-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 108
ILE A 113
HIS A  12
VAL A 182
 None
None
ZN  A   1 (-3.5A)
None
 1.17A 4a97I-1bf6A:
undetectable		 4a97I-1bf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 205
ARG A 181
SER A 180
 None
 1.17A 4dr2I-1bf6A:
0.0
4dr2J-1bf6A:
0.0		 4dr2I-1bf6A:
18.21
4dr2J-1bf6A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 12 GLU A 125
ILE A 126
PHE A 291
ILE A 122
PHE A 290
 ZN  A 293 ( 2.5A)
None
None
None
None
 1.18A 4fglA-1bf6A:
undetectable
4fglB-1bf6A:
undetectable		 4fglA-1bf6A:
19.06
4fglB-1bf6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 5 HIS A  12
HIS A 158
HIS A 186
ASP A 243
 ZN  A   1 (-3.5A)
ZN  A 293 (-3.3A)
ZN  A 293 (-3.3A)
ZN  A   1 (-2.7A)
 0.81A 4h9mA-1bf6A:
4.7		 4h9mA-1bf6A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 188
LEU A 229
VAL A 279
 None
 0.71A 4jecB-1bf6A:
undetectable		 4jecB-1bf6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 TYR A 205
ARG A 181
SER A 180
 None
 0.93A 4khpI-1bf6A:
0.0
4khpJ-1bf6A:
0.0		 4khpI-1bf6A:
18.93
4khpJ-1bf6A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 6 LEU A 189
HIS A  12
HIS A  14
TYR A  84
GLU A 125
 None
ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
None
ZN  A 293 ( 2.5A)
 1.36A 4pahA-1bf6A:
undetectable		 4pahA-1bf6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 12 TYR A  83
HIS A 186
HIS A 158
GLY A 127
ASP A 243
 None
ZN  A 293 (-3.3A)
ZN  A 293 (-3.3A)
None
ZN  A   1 (-2.7A)
 1.21A 4qa2A-1bf6A:
undetectable		 4qa2A-1bf6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 TYR A   8
LEU A 262
GLN A 276
ARG A 270
 None
 1.02A 4qzuB-1bf6A:
0.0		 4qzuB-1bf6A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 6 HIS A  12
HIS A  14
HIS A 158
HIS A 186
ASP A 243
 ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
ZN  A 293 (-3.3A)
ZN  A 293 (-3.3A)
ZN  A   1 (-2.7A)
 0.67A 4ubpC-1bf6A:
13.4		 4ubpC-1bf6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 188
VAL A 238
LEU A 229
 None
 0.49A 5e5jB-1bf6A:
undetectable		 5e5jB-1bf6A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 12 GLU A 125
VAL A 177
LEU A 169
GLY A 165
THR A 159
 ZN  A 293 ( 2.5A)
None
None
None
None
 1.46A 5igpA-1bf6A:
1.0		 5igpA-1bf6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 4 HIS A  12
HIS A  14
TYR A  84
GLU A 125
 ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
None
ZN  A 293 ( 2.5A)
 1.06A 5pahA-1bf6A:
undetectable		 5pahA-1bf6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 7 MET A 164
VAL A 184
PHE A 141
GLU A 167
 SO4  A 294 (-3.6A)
None
None
SO4  A 294 ( 4.5A)
 1.42A 5vv5A-1bf6A:
0.0
5vv5B-1bf6A:
0.5		 5vv5A-1bf6A:
22.58
5vv5B-1bf6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		5 / 12 SER A 162
THR A 159
PHE A 208
LEU A 226
TYR A 217
 None
 1.27A 6a93A-1bf6A:
undetectable		 6a93A-1bf6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 5 THR A 245
HIS A  12
ASP A 209
HIS A 186
 SO4  A 295 (-3.3A)
ZN  A   1 (-3.5A)
None
ZN  A 293 (-3.3A)
 1.46A 6dchA-1bf6A:
undetectable		 6dchA-1bf6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN
(Escherichia
coli) 		4 / 6 HIS A  12
HIS A  14
TYR A  84
GLU A 125
 ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
None
ZN  A 293 ( 2.5A)
 1.08A 6pahA-1bf6A:
undetectable		 6pahA-1bf6A:
20.92