SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		3 / 3 LEU A 104
PRO A 105
LEU A 108
 None
 0.54A 1hrkA-1bixA:
undetectable		 1hrkA-1bixA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		3 / 3 LEU A 104
PRO A 105
LEU A 108
 None
 0.63A 2po5B-1bixA:
undetectable		 2po5B-1bixA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		3 / 3 ARG A 254
ASN A 212
THR A 265
 None
 0.74A 2q63A-1bixA:
0.0		 2q63A-1bixA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		3 / 3 LEU A 104
PRO A 105
LEU A 108
 None
 0.50A 3hcrA-1bixA:
0.0		 3hcrA-1bixA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 6 ASP A 219
ASP A 251
SER A 298
ALA A 263
 None
 1.18A 4nedA-1bixA:
undetectable		 4nedA-1bixA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 4 ASN A 277
LEU A 305
PHE A 266
TYR A 269
 None
 1.38A 4u14A-1bixA:
undetectable		 4u14A-1bixA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 5 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.01A 5iy5P-1bixA:
1.1
5iy5W-1bixA:
0.0		 5iy5P-1bixA:
18.33
5iy5W-1bixA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		5 / 8 ALA A 170
LEU A 205
LEU A 199
LEU A 243
LEU A 249
 None
 1.30A 5jqbA-1bixA:
0.0
5jqbB-1bixA:
0.0		 5jqbA-1bixA:
21.81
5jqbB-1bixA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 6 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.09A 5w97C-1bixA:
1.1
5w97J-1bixA:
undetectable		 5w97C-1bixA:
18.33
5w97J-1bixA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 5 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.03A 5x1fC-1bixA:
1.2
5x1fJ-1bixA:
0.0		 5x1fC-1bixA:
18.33
5x1fJ-1bixA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 5 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.04A 5xdxC-1bixA:
1.2
5xdxJ-1bixA:
0.0		 5xdxC-1bixA:
18.33
5xdxJ-1bixA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 5 LEU A 205
PHE A 165
LEU A 199
PHE A 195
 None
 1.04A 5xdxP-1bixA:
1.1
5xdxW-1bixA:
0.0		 5xdxP-1bixA:
18.33
5xdxW-1bixA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 5 ILE A  91
SER A 135
LEU A 316
LYS A  58
 None
 0.99A 6dwnA-1bixA:
0.0		 6dwnA-1bixA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1bix AP ENDONUCLEASE 1
(Homo
sapiens) 		4 / 6 ASP A 283
TYR A 171
GLU A  96
ASP A  70
 None
None
SM  A 401 (-2.3A)
SM  A 401 (-3.3A)
 1.43A 6mn5A-1bixA:
0.0		 6mn5A-1bixA:
15.94