SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bjw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.16A 1e7bA-1bjwA:
0.0		 1e7bA-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.20A 1e7bB-1bjwA:
0.0		 1e7bB-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 5 ARG A  55
ALA A  56
ALA A 274
GLU A 277
 None
 1.21A 1e7cA-1bjwA:
0.1		 1e7cA-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ARG A 316
LEU A 304
PRO A 123
GLY A 178
 None
 1.00A 1hrkB-1bjwA:
undetectable		 1hrkB-1bjwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 104
GLY A 244
GLY A  99
ILE A 205
LEU A 200
 None
LLP  A 234 ( 4.9A)
LLP  A 234 ( 3.5A)
LLP  A 234 ( 4.0A)
None
 1.21A 1p91A-1bjwA:
3.1		 1p91A-1bjwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 SER A 266
LEU A  73
VAL A  96
VAL A  49
ALA A 274
 None
 1.04A 1q23H-1bjwA:
1.1
1q23I-1bjwA:
1.5		 1q23H-1bjwA:
21.17
1q23I-1bjwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 THR A 265
PRO A 267
PRO A  67
 None
 0.84A 2d55C-1bjwA:
undetectable		 2d55C-1bjwA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 307
LEU A 362
VAL A 348
ILE A 330
PHE A 378
 None
 1.13A 2weyA-1bjwA:
undetectable		 2weyA-1bjwA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 4 GLY A  39
GLU A  40
ASP A  42
TYR A 296
 PO4  A 414 (-3.2A)
None
None
None
 1.37A 2yvlC-1bjwA:
4.0		 2yvlC-1bjwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A  99
GLY A 231
GLY A 244
 LLP  A 234 ( 3.5A)
None
LLP  A 234 ( 4.9A)
 0.37A 3bogD-1bjwA:
0.0		 3bogD-1bjwA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 VAL A 118
VAL A 120
LEU A 121
SER A 122
 None
 0.89A 3hs6B-1bjwA:
0.0		 3hs6B-1bjwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLU A  84
GLU A 207
TYR A 245
PHE A  81
 None
 1.05A 3ku9B-1bjwA:
undetectable		 3ku9B-1bjwA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLU A 204
GLU A  84
ASN A  85
 None
 0.89A 3lp9B-1bjwA:
undetectable
3lp9D-1bjwA:
undetectable		 3lp9B-1bjwA:
17.14
3lp9D-1bjwA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PRO A 218
SER A 202
ASN A  85
 None
 0.83A 3lslG-1bjwA:
0.0		 3lslG-1bjwA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 VAL A 120
LEU A 112
SER A 127
PHE A 105
VAL A 169
 None
 1.14A 4eckB-1bjwA:
2.1		 4eckB-1bjwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A 120
SER A 127
PHE A 105
LEU A 104
VAL A 169
 None
 1.09A 4eilC-1bjwA:
undetectable		 4eilC-1bjwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A 120
SER A 127
PHE A 105
LEU A 104
VAL A 169
 None
 1.12A 4eilE-1bjwA:
undetectable		 4eilE-1bjwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 312
LEU A 307
LEU A 303
ILE A 330
VAL A 346
 None
 1.09A 4f4dA-1bjwA:
0.9		 4f4dA-1bjwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 8 LEU A 312
LEU A 307
LEU A 303
ILE A 330
VAL A 346
 None
 1.13A 4klaA-1bjwA:
0.5		 4klaA-1bjwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 9 ALA A 374
ASP A  32
LEU A  33
GLY A 345
LEU A  36
 None
 1.17A 5dqfA-1bjwA:
undetectable		 5dqfA-1bjwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		3 / 3 PRO A  91
ARG A  74
GLU A  75
 None
 0.85A 5j6hA-1bjwA:
0.0		 5j6hA-1bjwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 232
GLY A 244
THR A  97
GLY A 100
ASN A 230
 None
LLP  A 234 ( 4.9A)
None
LLP  A 234 ( 3.6A)
None
 1.10A 5ybbA-1bjwA:
undetectable		 5ybbA-1bjwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1bjw ASPARTATE
AMINOTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 235
PHE A 354
VAL A 126
VAL A 349
ALA A 365
 LLP  A 234 ( 3.7A)
None
None
None
None
 1.05A 6djzC-1bjwA:
0.0		 6djzC-1bjwA:
23.43