SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 283
PRO A 250
LEU A 212
THR A 236
 None
 1.27A 1i2wA-1bk6A:
undetectable		 1i2wA-1bk6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 164
LYS A 167
ASP A 171
ALA A 172
 None
 0.37A 1iwhA-1bk6A:
undetectable		 1iwhA-1bk6A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 388
LEU A 384
LYS A 358
GLU A 355
ALA A 361
 None
 1.36A 1sn0A-1bk6A:
undetectable
1sn0C-1bk6A:
undetectable		 1sn0A-1bk6A:
18.29
1sn0C-1bk6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 327
VAL A 336
ASP A 381
 None
 0.78A 2fumD-1bk6A:
0.0		 2fumD-1bk6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 350
ILE A 365
ILE A 292
LEU A 304
 None
 0.82A 2xkwB-1bk6A:
0.0		 2xkwB-1bk6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 365
LEU A 424
ASN A 454
LEU A 388
ILE A 385
 None
 1.16A 3a50B-1bk6A:
3.1		 3a50B-1bk6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 365
LEU A 424
ASN A 454
LEU A 388
ILE A 385
 None
 1.12A 3a50C-1bk6A:
2.9		 3a50C-1bk6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 365
LEU A 424
ASN A 454
LEU A 388
ILE A 385
 None
 1.12A 3a50E-1bk6A:
3.0		 3a50E-1bk6A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 368
ALA A 340
VAL A 323
VAL A 327
 None
 0.90A 3me6B-1bk6A:
undetectable		 3me6B-1bk6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 357
GLN A 316
ALA A 319
LEU A 320
 None
 0.66A 3ozwA-1bk6A:
undetectable		 3ozwA-1bk6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 357
HIS A 310
GLN A 316
ALA A 319
LEU A 320
LEU A 346
 None
 1.40A 3ozwB-1bk6A:
undetectable		 3ozwB-1bk6A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 195
TRP A 237
THR A 238
 None
 1.40A 4bboB-1bk6A:
undetectable		 4bboB-1bk6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 11 THR A 238
TRP A 195
ALA A 159
THR A 166
VAL A 170
 None
 1.15A 4e0fA-1bk6A:
undetectable		 4e0fA-1bk6A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 480
GLY A 481
ASP A 441
ASP A 435
 None
 1.00A 4n48A-1bk6A:
undetectable		 4n48A-1bk6A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 182
LEU A 197
ASN A 199
THR A 166
ALA A 152
 None
 0.96A 4x1kA-1bk6A:
undetectable
4x1kB-1bk6A:
undetectable		 4x1kA-1bk6A:
22.56
4x1kB-1bk6A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1bk6 KARYOPHERIN ALPHA
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 182
THR A 166
VAL A 170
THR A 238
LEU A 239
 None
 1.27A 6djzB-1bk6A:
undetectable		 6djzB-1bk6A:
17.97