SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		5 / 12 LEU S 872
SER S 876
VAL S 927
LEU S 795
HIS S 827
 None
 1.34A 1db1A-1bkdS:
undetectable		 1db1A-1bkdS:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		5 / 12 LEU S 872
SER S 876
VAL S 927
LEU S 795
HIS S 827
 None
 1.42A 1rk3A-1bkdS:
undetectable		 1rk3A-1bkdS:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		3 / 3 THR S 605
ASP S 573
SER S 571
 None
 0.77A 2nxeA-1bkdS:
undetectable		 2nxeA-1bkdS:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		3 / 3 THR S 605
ASP S 573
SER S 571
 None
 0.82A 2nxeB-1bkdS:
undetectable		 2nxeB-1bkdS:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 6 PHE S 634
TYR S 631
CYH S 635
PHE S 627
 None
 0.91A 3ltwA-1bkdS:
undetectable		 3ltwA-1bkdS:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 5 LEU S 934
GLY S 931
MET S 824
ASN S 869
 None
 1.11A 3uq6B-1bkdS:
undetectable		 3uq6B-1bkdS:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		5 / 12 LEU S 872
SER S 876
VAL S 927
LEU S 795
HIS S 827
 None
 1.41A 3vt3A-1bkdS:
undetectable		 3vt3A-1bkdS:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 8 GLU S 792
LEU S 919
LEU S 872
GLY S 931
 None
 0.83A 4r3aA-1bkdS:
undetectable		 4r3aA-1bkdS:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		3 / 3 PHE S 717
ILE S 644
ASP S 703
 None
 0.45A 5cswA-1bkdS:
0.6		 5cswA-1bkdS:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		3 / 3 PHE S 717
ILE S 644
ASP S 703
 None
 0.43A 5cswB-1bkdS:
0.0		 5cswB-1bkdS:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 5 LEU S 640
PHE S 958
LEU S 613
HIS S 700
 None
 1.04A 5gtrA-1bkdS:
1.6		 5gtrA-1bkdS:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		5 / 9 LEU S 788
HIS S 827
ILE S 855
GLU S 857
VAL S 861
 None
 0.70A 5igzA-1bkdS:
undetectable		 5igzA-1bkdS:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		5 / 10 LEU S 776
ILE S 784
PHE S 835
PRO S 781
VAL S 874
 None
 1.34A 5m0oA-1bkdS:
0.0		 5m0oA-1bkdS:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 7 HIS S 695
HIS S 700
LEU S 640
VAL S 624
 None
 1.01A 5m8rA-1bkdS:
undetectable		 5m8rA-1bkdS:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 8 HIS S 695
HIS S 700
LEU S 640
VAL S 624
 None
 1.00A 5m8rD-1bkdS:
undetectable		 5m8rD-1bkdS:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 5 PHE S 929
PHE S 930
LEU S 934
LEU S 919
 None
 1.35A 5veuH-1bkdS:
0.0		 5veuH-1bkdS:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 7 HIS S 780
PRO S 781
ILE S 782
SER S 853
 None
 0.86A 5vkqA-1bkdS:
0.0
5vkqD-1bkdS:
0.0		 5vkqA-1bkdS:
14.28
5vkqD-1bkdS:
14.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		3 / 3 LYS S 602
LEU S 948
ARG S 950
 None
 0.82A 5yw0A-1bkdS:
0.0		 5yw0A-1bkdS:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1bkd SON OF SEVENLESS-1
(Homo
sapiens) 		4 / 4 ASP S 775
ILE S 784
PRO S 781
LEU S 779
 None
 1.49A 6mkeB-1bkdS:
0.0		 6mkeB-1bkdS:
10.60