SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 PHE A 393
ASN A 352
ILE A 320
GLY A 321
 None
None
None
NAP  A   2 ( 3.9A)
 1.00A 1oniA-1bl5A:
0.5
1oniB-1bl5A:
0.5		 1oniA-1bl5A:
17.75
1oniB-1bl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 PHE A 393
ASN A 352
ILE A 320
GLY A 321
 None
None
None
NAP  A   2 ( 3.9A)
 1.00A 1oniD-1bl5A:
0.0
1oniF-1bl5A:
0.1		 1oniD-1bl5A:
17.75
1oniF-1bl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 ILE A 320
GLY A 321
PHE A 393
ASN A 352
 None
NAP  A   2 ( 3.9A)
None
None
 1.01A 1oniG-1bl5A:
0.1
1oniI-1bl5A:
0.6		 1oniG-1bl5A:
17.75
1oniI-1bl5A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 ALA A 337
GLY A  34
PRO A  43
ALA A  44
ILE A 356
 None
 0.89A 1rl8A-1bl5A:
undetectable		 1rl8A-1bl5A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ALA A 337
ILE A  37
GLY A 321
ILE A 322
 None
None
NAP  A   2 ( 3.9A)
None
 0.72A 2o4nB-1bl5A:
undetectable		 2o4nB-1bl5A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 THR A 341
SER A 355
SER A 359
VAL A  41
GLY A  38
 None
 1.48A 2x2iD-1bl5A:
0.3		 2x2iD-1bl5A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 310
GLU A 336
ASP A 307
 None
AKG  A   1 ( 4.6A)
MG  A 418 (-3.1A)
 0.71A 2zthA-1bl5A:
2.6		 2zthA-1bl5A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 310
GLU A 336
ASP A 307
 None
AKG  A   1 ( 4.6A)
MG  A 418 (-3.1A)
 0.69A 3bwmA-1bl5A:
undetectable		 3bwmA-1bl5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 310
GLU A 336
ASP A 307
 None
AKG  A   1 ( 4.6A)
MG  A 418 (-3.1A)
 0.71A 3bwyA-1bl5A:
undetectable		 3bwyA-1bl5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 8 ALA A 360
VAL A  48
GLY A 354
ILE A 322
ILE A 376
 None
 1.15A 3ekpA-1bl5A:
undetectable		 3ekpA-1bl5A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  38
ALA A 337
PRO A  43
ALA A  44
ALA A 342
 None
None
None
None
NAP  A   2 (-4.0A)
 1.08A 3jb3A-1bl5A:
2.1		 3jb3A-1bl5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 GLU A 121
LEU A 122
ASP A 123
 None
 0.44A 3ko0A-1bl5A:
undetectable		 3ko0A-1bl5A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A 290
ALA A 312
ASP A 311
GLY A 319
PRO A 144
 None
None
MG  A 418 ( 3.9A)
None
None
 1.24A 3oxxB-1bl5A:
0.0		 3oxxB-1bl5A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 HIS A 366
GLY A 329
ILE A 328
 None
 0.62A 4k50A-1bl5A:
undetectable		 4k50A-1bl5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 HIS A 366
GLY A 329
ILE A 328
 None
 0.61A 4k50I-1bl5A:
undetectable		 4k50I-1bl5A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ASP A 221
ALA A 219
TYR A 216
ASP A 223
 None
 1.18A 4mdaA-1bl5A:
0.0		 4mdaA-1bl5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 ASP A 221
ALA A 219
TYR A 216
ASP A 223
 None
 1.21A 4mdbA-1bl5A:
undetectable		 4mdbA-1bl5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 PRO A  30
MET A  66
TYR A  95
 None
 1.04A 4qa0B-1bl5A:
3.0		 4qa0B-1bl5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 PRO A  30
MET A  66
TYR A  95
 None
 1.09A 4qa0A-1bl5A:
0.3		 4qa0A-1bl5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 SER A 310
GLU A 336
ASP A 307
 None
AKG  A   1 ( 4.6A)
MG  A 418 (-3.1A)
 0.68A 4xudA-1bl5A:
undetectable		 4xudA-1bl5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 GLY A  34
PHE A 393
ILE A 384
GLY A 319
THR A 341
 None
 1.06A 5eskA-1bl5A:
0.0		 5eskA-1bl5A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 7 SER A 359
LEU A 364
THR A 370
ALA A 373
 None
 0.62A 5o96C-1bl5A:
2.8		 5o96C-1bl5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 VAL A  49
GLY A  38
VAL A  41
MET A  45
GLY A  34
 None
 1.39A 5zniA-1bl5A:
undetectable		 5zniA-1bl5A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1bl5 ISOCITRATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 TYR A 296
VAL A 276
VAL A 225
THR A 226
 None
 1.34A 6f32B-1bl5A:
undetectable		 6f32B-1bl5A:
23.29