SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bmt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	5 / 9	LEU A 831 VAL A 766 TYR A 775 GLY A 767 LEU A 800	COB A 122 (-4.4A) COB A 122 ( 4.6A) None None None	1.28A	1ikvA-1bmtA: 1.7	1ikvA-1bmtA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PBC_A_BHAA396_0 (P-HYDROXYBENZOATE HYDROXYLASE)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	5 / 10	GLY A 865 VAL A 866 LEU A 831 TYR A 775 ALA A 869	None None COB A 122 (-4.4A) None None	1.25A	1pbcA-1bmtA: 3.3	1pbcA-1bmtA: 20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ERD_B_DESB800_1 (ESTROGEN RECEPTOR ALPHA)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	5 / 10	ALA A 682 LEU A 697 LEU A 663 ARG A 662 LEU A 732	None	1.41A	3erdB-1bmtA: 0.0	3erdB-1bmtA: 21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NV6_A_CAMA422_0 (CYTOCHROME P450)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	3 / 3	GLY A 833 ILE A 765 VAL A 766	COB A 122 ( 3.8A) COB A 122 (-4.0A) COB A 122 ( 4.6A)	0.47A	3nv6A-1bmtA: 0.0	3nv6A-1bmtA: 22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DO3_A_0LAA602_1 (FATTY-ACID AMIDE HYDROLASE 1)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	4 / 5	LEU A 870 LEU A 831 MET A 749 THR A 863	None COB A 122 (-4.4A) None COB A 122 (-3.4A)	1.45A	4do3A-1bmtA: 1.0	4do3A-1bmtA: 16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RZV_B_032B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	4 / 5	ILE A 832 SER A 838 HIS A 841 ASP A 757	None None None COB A 122 (-4.1A)	1.20A	4rzvB-1bmtA: undetectable	4rzvB-1bmtA: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZDY_A_1YNA602_2 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	3 / 3	ALA A 728 TYR A 731 PRO A 689	None	0.68A	4zdyA-1bmtA: 0.0	4zdyA-1bmtA: 19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_B_08JB602_1 (CYTOCHROME P450 3A4)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	4 / 8	ALA A 818 ILE A 789 ALA A 786 LEU A 790	None	0.82A	5te8B-1bmtA: 0.0	5te8B-1bmtA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSG_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	5 / 10	LEU A 831 VAL A 766 TYR A 775 GLY A 767 LEU A 800	COB A 122 (-4.4A) COB A 122 ( 4.6A) None None None	1.38A	6bsgA-1bmtA: 0.0	6bsgA-1bmtA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F8C_A_STRA502_1 (CYTOCHROME P450 CYP260A1)	1bmt	METHIONINE SYNTHASE (Escherichia coli)	4 / 6	ALA A 752 GLY A 834 THR A 837 ILE A 846	None COB A 122 (-3.6A) None None	0.89A	6f8cA-1bmtA: 0.0	6f8cA-1bmtA: 14.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IKV_A_EFZA2000_1","POL POLYPROTEIN","1bmt","METHIONINE SYNTHASE","Escherichia coli",5,"LEU A 831;VAL A 766;TYR A 775;GLY A 767;LEU A 800","COB A 122 (-4.4A);COB A 122 ( 4.6A);None;None;None","1.28A","1ikvA-1bmtA:1.7","1ikvA-1bmtA:18.97"],["1PBC_A_BHAA396_0","P-HYDROXYBENZOATE HYDROXYLASE","1bmt","METHIONINE SYNTHASE","Escherichia coli",5,"GLY A 865;VAL A 866;LEU A 831;TYR A 775;ALA A 869","None;None;COB A 122 (-4.4A);None;None","1.25A","1pbcA-1bmtA:3.3","1pbcA-1bmtA:20.41"],["3ERD_B_DESB800_1","ESTROGEN RECEPTOR ALPHA","1bmt","METHIONINE SYNTHASE","Escherichia coli",5,"ALA A 682;LEU A 697;LEU A 663;ARG A 662;LEU A 732","None","1.41A","3erdB-1bmtA:0.0","3erdB-1bmtA:21.15"],["3NV6_A_CAMA422_0","CYTOCHROME P450","1bmt","METHIONINE SYNTHASE","Escherichia coli",3,"GLY A 833;ILE A 765;VAL A 766","COB A 122 ( 3.8A);COB A 122 (-4.0A);COB A 122 ( 4.6A)","0.47A","3nv6A-1bmtA:0.0","3nv6A-1bmtA:22.34"],["4DO3_A_0LAA602_1","FATTY-ACID AMIDE HYDROLASE 1","1bmt","METHIONINE SYNTHASE","Escherichia coli",4,"LEU A 870;LEU A 831;MET A 749;THR A 863","None;COB A 122 (-4.4A);None;COB A 122 (-3.4A)","1.45A","4do3A-1bmtA:1.0","4do3A-1bmtA:16.90"],["4RZV_B_032B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","1bmt","METHIONINE SYNTHASE","Escherichia coli",4,"ILE A 832;SER A 838;HIS A 841;ASP A 757","None;None;None;COB A 122 (-4.1A)","1.20A","4rzvB-1bmtA:undetectable","4rzvB-1bmtA:22.73"],["4ZDY_A_1YNA602_2","LANOSTEROL 14-ALPHA DEMETHYLASE","1bmt","METHIONINE SYNTHASE","Escherichia coli",3,"ALA A 728;TYR A 731;PRO A 689","None","0.68A","4zdyA-1bmtA:0.0","4zdyA-1bmtA:19.96"],["5TE8_B_08JB602_1","CYTOCHROME P450 3A4","1bmt","METHIONINE SYNTHASE","Escherichia coli",4,"ALA A 818;ILE A 789;ALA A 786;LEU A 790","None","0.82A","5te8B-1bmtA:0.0","5te8B-1bmtA:19.35"],["6BSG_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","1bmt","METHIONINE SYNTHASE","Escherichia coli",5,"LEU A 831;VAL A 766;TYR A 775;GLY A 767;LEU A 800","COB A 122 (-4.4A);COB A 122 ( 4.6A);None;None;None","1.38A","6bsgA-1bmtA:0.0","6bsgA-1bmtA:19.35"],["6F8C_A_STRA502_1","CYTOCHROME P450 CYP260A1","1bmt","METHIONINE SYNTHASE","Escherichia coli",4,"ALA A 752;GLY A 834;THR A 837;ILE A 846","None;COB A 122 (-3.6A);None;None","0.89A","6f8cA-1bmtA:0.0","6f8cA-1bmtA:14.83"]]